by Peter R. Breggin, M.D.
On April 29 the Washington Post confirmed that Eric Harris, the leader in the Littleton tragedy, was taking the psychiatric drug Luvox at the time of the murders. On April 30 the same newspaper published a story quoting expert claims that Luvox is safe and has no association with causing violence. In fact, Luvox and closely related drugs commonly produce manic psychoses, aggression, and other behavioral abnormalities in children and young people.
Luvox is a Selective Serotonin Reuptake Inhibitor (SSRI) that is approved for children and youth (up to age 17) for use in the treatment of obsessive compulsive disorder. However, doctors often give it for depression, since it is in the same SSRI class as Prozac, Zoloft, and Paxil.
According to the manufacturer, Solvay, 4% of children and youth taking Luvox developed mania during short-term controlled clinical trials. Mania is a psychosis which can produce bizarre, grandiose, highly elaborated destructive plans, including mass murder. Interestingly, in a recent controlled clinical trial, Prozac produced mania in the same age group at a rate of 6%. These are very high rates for drug-induced mania--much higher than those produced in adults. Yet the risk will be even higher during long-term clinical use where medical supervision, as in the case of Harris, is much more lax than in controlled clinical trials. These drugs also produce irritability, aggression or hostility, alienation, agitation, and loss of empathy.
Reports suggest that Eric Harris may have had a relatively good family life. If so, it adds to the probability that he was suffering from a drug-induced manic reaction caused by Luvox. The phenomenon of drug-induced manic reactions caused by antidepressants is so widely recognized that it is discussed several times in the Diagnostic and Statistical Manual of Mental Disorders of the American Psychiatric Association and many times in The Physicians' Desk Referenc