It's interesting that even at that early date the English settlers outnumbered the Indian natives. If you look at the early American birth rate, it was rather phenomenal. They could outbreed even bunny rabbits, while the American Indians had a much lower birth rate.
Plus, the English had at least a partial immunity to the diseases they brought with them like small pox and measles, and the completely defensive Indians had nothing equivalent to spread back to spread back to them while being decimated by European-born epidemics.
Oops, that should be "and the completely defenseless Indians", in reference to their total lack of immunity to European diseases.
If you look at the early American birth rate, it was rather phenomenal.
Other than work it's not like they had much else to do.
They used the long term "Tobacco habit" to get their revenge. ;-)