The written Word of God, the Holy bible, is proof of God’s use of the ungodly as a form of judgement on His People.
When all the believers are raptured, Islam will be free to carry out it’s quest for world domination. This is known as the tribulation.
The answer to your question is now until the rapture +7 years.
I think it’s more than Islam.
There are a large number of anti-God and anti-Christian people now and they will contribute mightily in the Tribulation.