It makes sense.
The very mechanism that God used to create unlimited variety in humans, DNA, when it became corrupted through sin, also produced bad changes, not good only.
And the bad changes are considered disease and deformities, etc.
Something gone wrong with the original mechanism that God never intended and would not have happened in a perfect, sinless world.
It’s part of the corruption of sin.
>Something gone wrong with the original mechanism that God never intended
Not likely in a perfect creator. More like “light fuse, get away”.