Jerusalem is the city where the people of God reside, i.e. the Church.
the only “holy place” after Jesus went to the cross is the Church.
Jesus is warning that near the end of the world, Satan will be loosed for a short while, evil will multiple, there will be a great falling away from the Church such that Jesus asked whether He would still find faith on the earth when He returned and finally Satan will sit in the holy place, that is he will rule the Church. everything is playing out exactly as the Scriptures tell us they will.
The “church” did NOT replace the nation of Israel. As God promised the Israelites are being brought back to their promised land. The armed nations around Israel is just now starting.
Jerusalem here is the object of God's wrath. It cannot, therefore, be defined as the Church:
"That upon you may come all the righteous blood shed upon the earth, from the blood of righteous Abel unto the blood of Zacharias son of Barachias, whom ye slew between the temple and the altar. Verily I say unto you, All these things shall come upon this generation. O Jerusalem, Jerusalem, thou that killest the prophets, and stonest them which are sent unto thee, how often would I have gathered thy children together, even as a hen gathereth her chickens under her wings, and ye would not! Behold, your house is left unto you desolate." (Mat 23:35-38)