I know what the Bible says, according to the Genesis quote you gave. The problem is ... I don’t know if those tetrads are what is being talked about in Genesis 1:14.
So, they may not be a “sign” from God, any more than the Comet ISON is a sign from God. If the Comet ISON is a “sign from God” - then I would like to know what it is a sign of, or about (if someone happens to think that).
Not everything that happens every single night in the sky is a sign from God. Every lunar eclipse is not a sign from God. Every solar eclipse is not a sign from God. Every comet is not a sign from God. The meteorite that hit Russia a little while back is not a sign from God. Haley’s Comet is not a sign from God. The meteorite that hit Winslow, Arizona and made a mile-wide crater is not a sign from God.
Regardless of the above, though, one thing is for sure, though, there is a pattern in those tetrads, and I’ll be curious to see if something develops in connection with the upcoming tetrad.