"Who are my mother and my brothers?" he asked.
Then he looked at those seated in a circle around him and said, "Here are my mother and my brothers! Whoever does God's will is my brother and sister and mother."
The connection between Mary are brothers here is very strong. It is evidence that indicates a high probability that these are in fact Jesus' bros and Mary's sons here. This can not be dismisssed, and stands in the contradiction to the pertual virginity claim. This passage makes the claim highly doubtful.
John 7:3Jesus' brothers said to him, "You ought to leave here and go to Judea, so that your disciples may see the miracles you do.
"And it would seem strange that Jude would call himself a brother of James, who supposedly is a blood brother of Jesus according to you,"
I madeno such claim. The above passages absolutely do not contain bros, as in good buddies. The above passages came before that and it's more probable that the bros are bros, not cousins.
I beleive Quester pointed to this verse as well.
Look, this has nothing to do with perpetual virginity of Mary because all Jesus does in this passage is to call every Christian his brother. In fact, this is another reason why all the references to "brethren of Our Lord" are problematic.