As another example, Wimmer's creation of the polio virus in a test tube began with an information sequence converted from the DNA to RNA (RNA cannot be synthesized) - after which he provided a cell free juice (human cell with mitochondria, nucleus removed) whereupon the virus built itself.
The key element here - which was unknown to Urey/Miller 1950's experiments - was information, both the message and its successful communication.
Thank you so much for your excellent essay-posts!