South Park has offended people for 9, count 'em, NINE years.
This won't change anything and you can bet Matt and Trey are making notes.
Like I said to another poster, offending people is permissible. Making fun of Christianity is also permissible. Blasphemy is not permissible. I just did some research and found descriptions of some other episodes making fun of Christ or Christmas. While they offend me personally, I would not demand that they pull them, because they put Christ in a comical context but not obscene context. For example, the episode where Santa tosses Christ like a lollypop is offensive, but it is also a valid commentary on how many Christians treat Christmas, and that excuses the episode as a valid satire. The menstrual blood of Mary episode is purely obscene and crossed the line into blasphemy for that reason.