One report suggests that there were slits in the envelopes through which a hypodermic needle could have been inserted.
I just try to "think" how I would have to do this and the pre-loaded syringe concept works best. So did they have many pre-loaded (throw-away) (1 oz) syringes?? or did they extract it through the seal of a 1 oz vial and insert it into the envelopes??