I wold use a .45 ACP 165 grain hollowpoint bullet and work up the fastest load I could. That would also make a dandy Woodchuck or coyote load.
The longer you live the more toys you gather, counting from the date of your last divorce.
So9
Best and meanest load I've got is 250 grain copper jacketed round doing 1950-2000 fps .... that's enough to ruin someone's day in a hurry.