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Eli Lilly Settles Prozac Lawsuit
Channel 6 Indianopis ^ | 7:20 p.m. EST November 30, 2002 | AP

Posted on 12/02/2002 11:11:09 AM PST by Nov3

Eli Lilly Settles Prozac Lawsuit
Woman Claimed Drug Caused Suicidal Thoughts

POSTED: 7:20 p.m. EST November 30, 2002

INDIANAPOLIS -- Eli Lilly and Co. has settled a product-liability lawsuit brought by a woman who alleges the drug maker's anti-depressant Prozac caused suicidal thoughts and led her to slash her wrists.

Lilly settled the case last week for an undisclosed amount. The lawsuit, which sought $4.84 million in tangible damages, had been scheduled to go to trial Tuesday in U.S. District Court in Pittsburgh.

The complaint was filed two years ago by Diane Cassidy and her husband Melvin. In July 2000, the Monroeville, Pa., couple picketed outside Lilly's Indianapolis headquarters, handing out fliers proclaiming, "Lilly, how many people are maimed or dead on your drug today?"

The lawsuit alleged that Diane Cassidy's doctor prescribed Prozac to her for weight loss, leading to suicidal thoughts that led her to slash her wrists and overdose on a painkiller.

The overdose caused intracranial bleeding, which left Cassidy paralyzed on one side and mentally impaired, according to the lawsuit.

The Cassidys were represented by Houston trial lawyer Andy Vickery, who has negotiated settlements of several Prozac cases against Lilly.

Lilly said in a statement that it "made a business decision to settle ... for factors completely unrelated to the safety and efficacy of Prozac," The Indianapolis Star reported in a story Saturday. "Such factors included the extensive time demands that litigation would have placed upon our scientists, keeping them away from their primary objective of discovering lifesaving medicines."

Also last week, a new Prozac lawsuit was filed against Lilly in U.S. District Court in Georgia.

It raises a new claim that has not been raised in previous lawsuits over Prozac, which was approved by the U.S. Food and Drug Administration in 1987 and went on to become Lilly's top-selling drug.

The Georgia wrongful-death lawsuit alleges Lilly failed to publicize research showing some people are "poor metabolizers of Prozac," and a test can reveal if a patient might be affected.

That lawsuit, in which Vickery is assisting the plaintiff, was brought by William H. Shell, the widower of LaVerne M. Shell. She shot herself to death at age 63 in November 2000, 11 days after starting on a prescription of Prozac to treat migraine headaches.

The lawsuit says that a human enzyme dubbed CYP2D6 normally metabolizes or breaks down Prozac and similar drugs in the body, but fails to do so in a minority of people. In their bodies, the active ingredient in Prozac builds up to high levels, putting them at risk of violence and suicide, the lawsuit says.

Lilly spokesman Blair Austin said that company officials had not seen the lawsuit and could not comment on the new allegation.



TOPICS: Crime/Corruption; Culture/Society; Extended News; News/Current Events
KEYWORDS: mayhem; prosac; suicide
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To: Al B.
Serotonin boosters are by nature anorexic. )))

Well...can be. But people sometimes get so cuddly and laidback on the stuff that they start enjoying food more. I've seen a lot of good done with these classes of drugs. When you start giving lawyers a big percentage of the profits, you can count on increased prices and decreased availability.

41 posted on 12/02/2002 2:08:39 PM PST by Mamzelle
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To: palmer
Are they suing any patients who failed to inform themselves sufficiently to make better decisions?

Why don't the patients go ahead and prescribe it themselves?

The answer to both of those questions would be that they aren't doctors.

42 posted on 12/02/2002 2:09:48 PM PST by Nov3
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To: Mamzelle
When you start giving lawyers a big percentage of the profits, you can count on increased prices and decreased availability.

I be a lot of victims would have preferred that Eli Lilly charge more and market it more carefully. NOw the lawyers get the money from the insurance companies. Lilly gets their cash long ago and the victims are largely left out in the cold

43 posted on 12/02/2002 2:13:30 PM PST by Nov3
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To: palmer
Are they suing any patients who failed to inform themselves sufficiently to make better decisions?

I was informed of a 1% risk. If they flat out lied and caused me to take a bigger risk with my child than I would have accepted... I don't know what I will do. Enriching the lawyers seems ridiculous. But how else do we force them to be honest?

44 posted on 12/02/2002 2:21:40 PM PST by Dianna
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To: robertpaulsen
Doctors should be free to prescribe drugs for "off-label" uses, but then they need to be held responsible, especially if they failed to monitor the patient properly and/or failed to warn the patient in advance of possible side effects which would warrant immediate discontinuation and a prompt visit to the doctor or an emergency room. There are some off-label uses of Prozac that are widely regarded by researchers and doctors as appropriate and effective. As far as I know (and I'm pretty well-read on the topic), weight loss isn't one of them (though of course if weight gain has resulted from depression, it might cause weight loss as a secondary effect of treating the underlying problem).
45 posted on 12/02/2002 2:26:10 PM PST by GovernmentShrinker
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To: Dianna
Researchers are currently working on commercially viable tests for the genetic peculiarities that cause a tiny percentage of people to react badly to certain drugs that help most users. Unfortunately those tests are not yet available, and doctors have little choice but to try the drug and hope for the best. This should be changing within a few years, as it becomes routine to test patients for inability to metabolize a drug before prescribing it.
46 posted on 12/02/2002 2:32:28 PM PST by GovernmentShrinker
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To: GovernmentShrinker
Doctors should be free to prescribe drugs for "off-label" uses, but then they need to be held responsible, especially if they failed to monitor the patient properly and/or failed to warn the patient in advance of possible side effects which would warrant immediate discontinuation and a prompt visit to the doctor or an emergency room.

Off label uses are an important and necessary part of medicine. However when a manufacturer promotes a tool and I believe a drug for some other use than it was approved for I believe it can be called misbranding by the FDA in some cases. This is not good for the company as far as legal protections are concerned. A doctor choices in treatment are one thing, the drug or tool companies choices are another.

That being said I think Lilly immediately came out and said that prosac should not be used as an adjunct to phentermine in weight loss when Phen-fen was pulled and doctor started subbing prosac. That would make it an off label use by a doctor.

47 posted on 12/02/2002 2:49:27 PM PST by Nov3
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To: GovernmentShrinker
That would make it an off label use by a doctor.

Unless Lilly promoted it for that use.
48 posted on 12/02/2002 2:50:16 PM PST by Nov3
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To: Nov3
I have no problem with people who want their doctor to give them a placebo (or other pill) because they believe it will make them better, but I personally would not use a doctor except to fix an obvious problem like a broken bone. A recent study (sorry I don't have a link) showed that placebos were as effective as anti-depressents. If your doctor decides to place his trust in a drug company selling expensive or even dangerous placebos, then there's a problem with medicine which can't be fixed by trial lawyers.
49 posted on 12/02/2002 3:09:53 PM PST by palmer
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To: Dianna
I was informed of a 1% risk. If they flat out lied and caused me to take a bigger risk with my child

First, you should inform yourself. I understand the desire to trust doctors though. Second, the risk needs to be traded off against results. Studies have shown placebos are as effective as these drugs, keeping in mind that the placebos are effective because people believe they are a drug that they have been told can make them better. Third, the right way to solve a medical problem is medical reform, not suing companies because risk assessments were inconclusive or inapplicable to *your* case in any event.

50 posted on 12/02/2002 3:24:51 PM PST by palmer
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To: palmer
First, you should inform yourself.

Errrrr Elli Lillyonly says it is one percent. She was lied to.

Third, the right way to solve a medical problem is medical reform, not suing companies because risk assessments were inconclusive or inapplicable to *your* case in any event.

Wrong answer. Eli Lilly recklessly sold this drug to everyone for everything to make MORE money. They could have made plenty just marketing it responsibly and reporting side effects. They should pay through the teeth if they caused the death and injury of others due to their actions or inaction. Our law does not allow them to be jailed. Only a deluded IDIOT would think they should walk away with the money after they trashed peoples lives.

51 posted on 12/02/2002 3:32:02 PM PST by Nov3
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To: palmer
Third, the right way to solve a medical problem is medical reform, not suing companies because risk assessments were inconclusive or inapplicable to *your* case in any event.

I read the patient insert. I questioned the Dr. What else am I supposed to do?

Medical reform like what? The drug companies are already not supposed to falsify information. The FDA is supposed to be making sure that they are honest. Again, I don't know if they were dishonest in this case.

It wasn't something weird, bizarre or unknown which happened to my son. Everyone knows this happens SOMETIMES. And if my kid was the one out of 100 patients affected this way, then that is perfectly fine. We knew we were taking a risk.

But if the rates of mania in non-manic patients is much higher than the drug company has stated, then I was denied the right to make an informed medical decision. THAT is my concern.

52 posted on 12/02/2002 5:17:55 PM PST by Dianna
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To: Petronski
Prozac for weight loss? I think that's off-label.

How about for smoking cessation? I have heard of a doc prescribing it for that too. Actually he didn't prescribe it he handed it out.

53 posted on 12/02/2002 5:34:34 PM PST by TigersEye
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To: matthew_the_brain
Real smart. Now the cost of the lawsuit is passed on to the consumers. The same people that applaud sh** like this will be bitching about the cost of prescription drugs.
54 posted on 12/02/2002 5:52:27 PM PST by mrfixit514
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To: mrfixit514
Real smart. Now the cost of the lawsuit is passed on to the consumers. The same people that applaud sh** like this will be bitching about the cost of prescription drugs.

Yeah I agree. These people should just bend over and take it like a man. A gay man that is. I hope you get the chance to show the way you feel in your personal life. Maybe someone can hide the failings of a product and someone maybe your son dies as a result. You will be a real role model and inspiration to everyone here when you stand on principle and let it go on and happen again to someone else because you don't want to run up the cost of doing business!

That is the right thing to do. Just let it go on.

55 posted on 12/02/2002 6:42:56 PM PST by Nov3
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To: Dianna
I understand your willingness to trust the doctor and go along with his prescription. But there are other doctors, there are pro websites and con websites. If a review indicates possible risk then you need to research further. There are medical alternatives, and there are non-medical alternatives. But I can understand that sooner or later you have to make a decision and you made yours.
56 posted on 12/02/2002 7:08:50 PM PST by palmer
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To: Nov3
Eli Lilly recklessly sold this drug to everyone for everything to make MORE money. They could have made plenty just marketing it responsibly and reporting side effects. They should pay through the teeth if they caused the death and injury of others due to their actions or inaction. Our law does not allow them to be jailed. Only a deluded IDIOT would think they should walk away with the money after they trashed peoples lives.

Why do you think they maximize the revenue from this single drug? Is it the prohibitive testing costs for finding any possible risk from a new drug? Is it the threat of new lawsuits should any new drug be "shown" by a trial lawyer to "cause" injury?

The reason these drugs work for all these things is basically a placebo effect. That's how it works for depression and probably many other psychological illnesses and behaviors. People believe it works and the incidental chemical effect in the brain makes no difference. Other psychoactive drugs are much more disruptive to brain chemistry, they have no healing effect, the patient simply has to do that himself.

I don't know the merits of these various lawsuits, but I do know that they are not generally used to punish wrongdoers. Usually the costs are passed to insurance companies, shareholders, and consumers.

57 posted on 12/02/2002 7:18:53 PM PST by palmer
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Comment #58 Removed by Moderator

To: palmer
The reason these drugs work for all these things is basically a placebo effect.

And you rec'd your MD where?

Just because in certain studies the effect was the same, does not mean that these were valid studies and applicable to everyone - there are many ways to set these studies up. To jump to such conclusions, regardless of how it is reported, is irresponsible. Since we are dealing with brain chemistry, there may be significant differences between those who get better on the drug versus those in the control group getting better with a placebo.

If belief is so important, why didn't I get better with Prozac? God knows I thought I would. But I didn't. Perhaps I should have tried harder?!?

59 posted on 12/02/2002 9:29:00 PM PST by technochick99
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To: Mamzelle
But people sometimes get so cuddly and laidback on the stuff

I consider that my meds work, and that has yet to happen to me. I can be just as snarly as the rest of you people not on them.

This wasn't quite the 'chill pill' I mentioned on the other thread ;)

60 posted on 12/02/2002 9:36:23 PM PST by technochick99
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