For years I shot the 325 grain slugs, made with SSK molds, over a compressed charge of 21.5 gr. of 296. These were pretty stiff out of a 44mag, but never really bothered me unless I forgot earplugs (!). This was my 'bear country' berry-picking load, and would penetrate 18" of gravel pile w/ 80%+ retention. I can keep it on a paper plate at 100 yds. with open sights . . .
I think the secret of dealing with recoil in a revolver is to hold the grip with relaxed hands, and let the weight of the gun soak up the recoil. The revolver goes up pretty high at the shot, but I never had one fly out of my hands !!