Fast round with a sharp thwak to the hand. 50 rounds will probably leave your hand "ringing." Not the most pleasant to shoot. I prefer a soft shove like a 45 gives to the sharp sting of a .40. Good round in a small package. Pretty effective.
Also a 357 out of a 6 inch (even a 4 inch) barrel using 110 grain bullets is very pleasant to shoot (and therefore practice with).
I was born and bred a .45 ACP fan. I choked on my first purchase of a .40 S&W. I have since converted. I do consider it a shame the 10mm never caught on. It was initially entertained by the FBI who insisted on some watered down loads...About the same time, the .40 came along, and offered similar performance to the weakened loads, in a shorter case, and subsequently, available in smaller, and more concealable weapons. I'm not trying to imply that the .40 is a pipsqueak, I certainly would not want to be shot with one! Simply that the 10 is a great design, limited only by the fact that it has not caught on, and that has resulted in a dearth of factory ammo, and commercial ammo development. That is not a problem with the .40, as a very large number of civilian law enforcement agencies have embraced it, and it has, in its short life, proven itself time and again, under real world circumstances...
IMHO, one of the best factory pistols on the market today is the...
...chambered in .40S&W.