The only state there is any outside chance Trump could lose it would be Iowa because of the caucus structure that state is a wildcard.
However it has a horrible history of actually picking the final nominee.
I doubt Trump will lose Iowa but even if he does it won’t change the overall outcome.
When it’s all said and done Trump will be the nominee receiving well over 60%. If not over 70% of the primary votes
Iowa is weird. So somebody like Tim Scott may win Iowa. But it doesn't matter.