If he runs for President there's no doubt he'll fight IMO but unfortunately he would still need a period of time to adjust to the climate in Washington and we really don't have that time. Plus he will want to run for a second term so there’s that and all that means.
Whereas Trump can hit the ground running without that learning curve De Santis will need. Additionally Trump has just 4 yrs then to accomplish his feats for the nation so he's not going to let any grass grow under his feet.
I like DeSantis and all he's done for his state. However I think better to know the Washington terrain well and DeSantis doesn't have that edge.
Did you forget that Desantis has already been in Washington? He has a lot more experience than Trump did when he took office - which is probably why he has been able to run such a tight and effective administration as governor.