I don't know of any blockades at the state border. There were none here in Florida, that I am aware of, and I'm doubtful they ever happened, as I never heard of any, and had relatives come visit via intra-state road travel without any incident whatsoever.
However, regarding "guidance," that is in fact the exact term that Trump used, when he announced his quote "new guidelines for every American to follow." Trump's guidelines were for quote "all Americans, including the young and healthy" and included not gathering in groups of more than 10 people, avoiding any discretionary travel, and restrictions from eating in any restaurant.
So no, my family did not follow Trump's guidelines, which we thought were ridiculously foolish. Nor did DeSantis do anything to impede their travel in or out of the state, or us eating at restaurants, etc.
A link direct to Trump's full announcement is still on the White House website, and a direct link can be found in post 37 of this thread. Thanks.
There are at least a few Florida Freepers here who reported getting stopped at the Florida border while driving back there from Georgia. And for reasons I’ll never understand, they all seemed to be perfectly comfortable with it.