The potential for second of third generation effects may be limited. I think this bunch is more interested in mutations that cause lethality shortly after fertilization. Time will tell, though.
There is evidence that mRNA therapy like the Covid (so called) Vaccine, can change RNA and that will be passed to the following generations.
It needs more research, but it has already been shown to be possible for this to happen. (contrary to pharma industry and the Fed Gov statements.)