Posted on 12/16/2021 6:25:40 PM PST by bitt
In late June, the University of Oxford announced that PRINCIPLE, one of the U.K. Government’s national priority platform trials of COVID-19 treatments, would be evaluating Ivermectin, the seventh treatment to be investigated in the PRINCIPLE trial. Along with the influenza antiviral drug favipiravir, Ivermectin, the “safe, broad-spectrum antiparasitic drug,” was added as part of the trial’s focus on treatment for people in the U.K. who have recently developed symptoms of COVID-19. Yet, suddenly, without an explanation from Merck—who is a key manufacturer of the generic, readily available drug Ivermectin—MedPage Today reports that PRINCIPLE’s trial on the drug is paused, stating:
“The Ivermectin arm of the U.K.’s PRINCIPLE trial is “currently paused due to temporary supply issues.”
With over 5,000 people signed up for the study, participants were randomly assigned to receive a three-day course of Ivermectin treatment. The trial was set to offer meaningful and much-anticipated data. And despite the current demand for Ivermectin, a robust supply is typically available, making the supply issue challenging to understand. Without question, the market caused by off-label usage has been substantial as prescriptions in the U.S. went from a few thousand per week pre-pandemic to nearly 90,000 per week during the pandemic. Nonetheless, this drug is straightforward to produce, and there are multiple suppliers.
MedPage Today, which boasts Marty Makary, MD, MPH as its Editor-in-Chief, reached out to both PRINCIPLE and Merck for a full explanation of the trial’s pause. By press time, according to MedPage Today, neither had offered more details. MedPage Reporter Jennifer Henderson wrote that Merck did not comment directly on any supply chain issues affecting PRINCIPLE’S trial. However, the pharmaceutical giant offered MedPage Today a longer statement in an email, saying:
(Excerpt) Read more at uncoverdc.com ...
p
I own stock in Merck, but their drug doesn’t seem to work as well as Ivermectin. Don’t tell the normies.
They probably want to reformulate it enough that they can re-patent the new variant and sell it for a thousand times as much as generic version which is off patent.
Yeah, the ivermectin might cut off their "supply" of government cash.
.
IVR PING
Wonder how much stock and investment our government has in this Merck venture?
IMASK+ and Dr. Zelenko both have 5- 7 days of Ivermectin, so it makes sense, in a way, that any drug trial would be half that length. :/
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It really works!
WHO lists ivermectin as an essential medicine every country should have a stockpile of.
Do the Brits not have enough for a simple trial? Where’d it all go? It’s not like anyone is using theirs except Africa and Japan!
I like it the way it is. Get used to it.
Hmm, here’s Merck again...
~PING~
Back to the Thread:
Check out # 6.
#6 awesome post! Egg
Meanwhile...
Disclose.tv
@disclosetv
JUST IN - South Africa hospitalization rate plunges to only 1.7% in #Omicron wave, compared with 19% in previous “Delta-driven” wave - Health Minister
7:08 AM · Dec 17, 2021
Big Pharm Mafia a made them pull the plug.
NOW WE KNOW IT WORKS!
Too much data to ignore:
“Ivermectin in COVID-19
These pages contain the scientific rationale that justifies the use of ivermectin in COVID-19.
We regard ivermectin as a core medication in the prevention and treatment of COVID-19. For comprehensive information on ivermectin please refer to our Review of the Emerging Evidence Supporting the Use of Ivermectin in the Prophylaxis and Treatment of COVID-19 and the included references.”
https://covid19criticalcare.com/ivermectin-in-covid-19/
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The Governement misleads America:
1) mRNA vaccines DO NOT provide immunity of any kind.No antibodies.
2) mRNA vaccines do not prevent transmisson of the virus.
3) mRNA vaccines do attenuate Covid symptoms if the Covid mutant variant is vulnerable, for a limited period of 5 months ( Pfizer) to 6 or 8 months ( Moderna).
4) The mRNA vaccines do not work in the nasal cavity, in the pharnyx or in the lung, they only work in the blood stream, but give no protection to Covid involved organs.IVM does.
Thats why Ivermectin in your friend when taken within a few days of the infection or as prophylaxis.
Proof of Effectiveness of Ivermectin:
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How Ivermectin works:
There is reasonably solid evidence that ivermectin docks to the spike protein itself to prevent binding to the ACE2 receptor which is the primary pathology causing the tissue damage and clots related to SARS-CoV-2. Therefore, this is also an implication that this ability of ivermectin to disable the binding of the Spike protein including the vaccine-produced spike proteins. This binding of ivermectin to disable the spike protein is also preserved even with the newer spike protein mutations, but its activity against the original Wuhan spike protein,(the one vaccines were designed to produce) is fairly well studied at this point.
Abstract:
Background/Aim: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One drug that has attracted interest is the antiparasitic compound ivermectin, a macrocyclic lactone derived from the bacterium Streptomyces avermitilis. We carried out a docking study to determine if ivermectin might be able to attach to the SARS-CoV-2 spike receptor-binding domain bound with ACE2. Materials and Methods: We used the program AutoDock Vina Extended to perform the docking study. Results: Ivermectin docked in the region of leucine 91 of the spike and histidine 378 of the ACE2 receptor. The binding energy of ivermectin to the spike-ACE2 complex was -18 kcal/mol and binding constant was 5.8 e-08.
Conclusion: The ivermectin docking we identified may interfere with the attachment of the spike to the human cell membrane. Clinical trials now underway should determine whether ivermectin is an effective treatment for SARS-Cov2 infection.
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The following video [ https://www.youtube.com/watch?v=11Bl2v3BR2M ] explains the multiple mechanisms of the activity of Ivermectin including the ability of the body to maintain its basic defense of the cell nucleus in preserving the body’s ability to produce antiviral proteins, inhibition of RNA dependant RNA polymerase which inhibits the replication of viral RNA (possibly including that from the mRNA vaccine package), the stat 3 human signaling pathway which inhibits the production of blood clots also possibly mitigating some of the vaccines most dangerous side effects. Also discussed is the inhibition of the CD147 pathway by ivermectin which again may block the clumping of platelets due to spike protein either from the virus or possibly the vaccines.
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IN FACT these Public Health commies do not want you to know about Ivermectin, that’s why they ridicule the drug and its use at every turn and suppress the news of Ivermectin’s effectiveness.
“FRONT LINE COVID-19 CRITICAL CARE ALLIANCE
PREVENTION & TREATMENT PROTOCOLS FOR COVID-19”
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How to get Ivermectin in the USA:
https://covid19criticalcare.com/ivermectin-in-covid-19/how-to-get-ivermectin/
OR take yur chances with:
India Mart:
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erck IVR
(h/t: patriots.win)
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