Posted on 11/11/2021 5:12:19 AM PST by Mount Athos
Almost one-third of new drugs approved by U.S. regulators over a decade ended up years later with warnings about unexpected, sometimes life-threatening side effects or complications, a new analysis found.
The results covered all 222 prescription drugs approved by the U.S. Food and Drug Administration from 2001 through 2010. The researchers looked at potential problems that cropped up during routine monitoring that's done once a medicine is on the market.
The 71 flagged drugs included top-sellers for treating depression, arthritis, infections and blood clots. Safety issues included risks for serious skin reactions, liver damage, cancer and even death.
"The large percentage of problems was a surprise," and they included side effects not seen during the review process, said Dr. Joseph Ross, the study's lead author and an associate professor of medicine and public health at Yale University.
While most safety concerns were not serious enough to prompt recalls, the findings raise questions about how thoroughly drugs are tested before approval, said drug safety expert Thomas Moore. But Ross said the results suggest that the FDA "is kind of doing a great job" at scrutinizing drugs after approval.
New drugs are generally tested first in hundreds or even thousands of people for safety and effectiveness.
"We know that safety concerns, new ones, are going to be identified once a drug is used in a wider population. That's just how it is," Ross said. "The fact that that's such a high number means the FDA is working hard to evaluate drugs and once concerns are identified, they're communicating them."
The researchers analyzed online FDA data on new drugs and the agency's later safety announcements. Problems surfaced on average about four years after approval. Results were published Tuesday in the Journal of the American Medical Association.
The FDA said in a statement that it performs post-market monitoring "to identify new safety information that may impact product labeling." The agency said it would review the study findings but declined to comment further.
"We know that safety concerns, new ones, are going to be identified once a drug is used in a wider population."
The study counted black-box warnings for dozens of drugs; these involved serious problems including deaths or life-threatening conditions linked with the drugs. There were also dozens of alerts for less serious potential harms and three drug withdrawals because of the potential for death or other serious harm.
Among the drugs with added warnings: Humira, used for arthritis and some other illnesses; Abilify, used for depression and other mental illness; and Pradaxa, a blood thinner. The withdrawn drugs and the reason: Bextra, an anti-inflammatory medicine, heart problems; Raptiva, a psoriasis drug, rare nervous system illness; and Zelnorm, a bowel illness drug, heart problems.
Safety issues were most common for psychiatric drugs and biologic drugs - made from living cells rather than chemicals - than for older drug types. Drugs brought to market through "accelerated" approval were slightly more likely to have later safety issues than those approved through conventional channels, a link seen in some previous research.
In recent years, there has been increasing pressure on the FDA from consumers and others to speed up its regulatory review process to get new drugs to the market sooner, Ross said.
Moore, a senior scientist for drug safety and policy at the Institute for Safe Medication Practices, said the new results raise concerns about whether new drugs are being extensively tested before approval. He noted that since 2011, drugs have increasingly been approved based on studies in small numbers of patients amid public criticism questioning whether the FDA is keeping potential cures away from patients.
"The answer is, you can't know whether they're valuable and lifesaving treatments unless you test them" adequately, Moore said.
PhRMA, a drug industry trade group, is reviewing the study, said spokeswoman Holly Campbell. In a statement, she said the industry is committed to post-market surveillance of new medicines, but added, "Even with rigorous clinical studies and regulatory review it may be impossible to detect certain safety signals until several years after approval, once the medicine is in broader use."
Whenever you see a commercial for any type of medication, there is a legal requirement to include warnings about possible side effects, allergic reactions, warnings for those with certain medical conditions, etc. The Republicans should introduce a bill calling for these same disclosures to be made during the commercials urging everyone to get the Covid vaccine.
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It’s cya for when the truth comes out.
Seems every drug advertised on tv gets sued within 3 years.
These are the approved drugs, not the experimental ones.
“Hospitals actively discourage reporting”
Here’s one personal story regarding side effects that may not be evident for years:
My mother was on Macrobid (nitrofurantoin) for years for Urinary Tract Infections (UTI). Background data….she had been a smoker all her adult life (40+ years) but quit in 1999.
When she was in her 70’s she suddenly had a hard time breathing. Ended up in a hospital after a bronchial-scope resulted in puncturing her lung….the same doctor then said it could be TB so she was quarantined for 3 days until she tested negative several times….she never tested positive.. I stayed with her in quarantine because the nurses didn’t want to come in the room.
Finally took her to a big city/university med center where they diagnosed her with a severe pulmonary fibrosis (scarring of the lungs)…a side effect of Macrobid they said. She was finally taken off the macrobid….did rehab to get off of oxygen (had to carry oxygen where ever she went…had oxygen setup in the house, etc) but the effects eventually overtook her and she passed away earlier than she should have.
Have you ever watched someone struggle to breathe? Who can’t catch their breath and the panicked look in their eyes? It is hard to watch….all i have to say is thank God for hospice and morphine. She was able to be lucid and calm during her last months of her life by treading that fine line between taking the edge off of her condition versus knocking her out to sleep the last of her days.
I will always be grateful that I had that time with her.
Side effects can have terrible long term consequences…..be sure to understand what potential these meds have especially if you are on them for a long time or they are newer meds.
Pharma execs get a job with the FDA then rotate back into their old jobs. It is about money and not saving lives.
Yep, and this is for drugs that actually HAVE gone through the standard, years-long, long term clinical safety trials. NONE of the “vaccines” are going through those trials.
So it’s a simple inference that we’ll probably discover more long-term effects from these drugs than we usually do, since any effects that we might have discovered during the safety trials will remain unknown, and we will just have to discover them the hard way.
Yes, you MUST take experimental untested drugs, but you MAY NOT take approved drugs we have decades of reliable data on.
My husband has rheumatoid arthritis and has taken methotrexate for many years.
This past year he was diagnosed with lung fibrosis.....caused by the methotrexate.
Ah good point. It wasn’t heresy yet.
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