Free Republic
Browse · Search
News/Activism
Topics · Post Article

To: RummyChick
The immune system is the trick.

Someone claimed that we will get cancer if we live long enough. The reason why we may never know it is because our immune system kicks in and kills it.

It is a fact that a weakened immune system increases your risk of getting cancer.

My uncle had RA and, I wasn't able to confirm, but I believe that they were treating him with immunosupressive drugs. He died of a very aggressive form of brain cancer.

19 posted on 10/20/2021 12:47:38 PM PDT by dhs12345
[ Post Reply | Private Reply | To 15 | View Replies ]


To: dhs12345

It’s more than that with some cancers. For example:

“Cancer possesses a flexible strategy to escape from immune surveillance. Highly expressed LDHA mediates tumor immune escape by inhibiting immune killing and promoting immunosuppression.”

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6308051/

Target the LDH-A and it may help the immune system with the cancer. This is why they keep focusing on research on LDH ....and why they need to look at the people that have that very rare disorder of deficiency.


23 posted on 10/20/2021 1:02:06 PM PDT by RummyChick
[ Post Reply | Private Reply | To 19 | View Replies ]

To: dhs12345

Immunotherepy for cancer is relatively new but limited successes have been impressive. The key discovery is that cancer cells which should be detected as foreign and destroyed naturally have evolved tricks used by native cells to suppress the activation of the immune system. Checkpoint blockade inhibitors are drugs that defeat this trick and let the T-cells go to work. The problem is that it requires a delicate balance and if the drugs are too effective they can produce a deadly autoimmune response when the body attacks its own cells as well. Early human trial volunteers actually paid with their lives before this balance was determined.

What this research indicates is that for some tumors just releasing the brakes isn’t enought to activate T-cells. They need an additional chemical signal to go into action. If this signal is isolated to just tumor cells it will kill the disease and leave the healthy cells alone.


27 posted on 10/20/2021 1:10:24 PM PDT by Dave Wright
[ Post Reply | Private Reply | To 19 | View Replies ]

Free Republic
Browse · Search
News/Activism
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson