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Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection
Cell Reports Medicine ^ | July 20,2021 | Kristen W Cohen et al.

Posted on 08/02/2021 8:20:17 PM PDT by packagingguy

The COVID-19 pandemic remains a global public health threat after 1 year of overwhelming disruption and loss. Overcoming the challenges to end the pandemic is accentuated by the recognition that SARS-CoV-2 can undergo rapid antigenic variation that may lower vaccine effectiveness in preventing new cases and progression to severe disease. Our findings show that most COVID-19 patients induce a wide-ranging immune defense against SARS-CoV-2 infection, encompassing antibodies and memory B cells recognizing both the RBD and other regions of the spike, broadly-specific and polyfunctional CD4+ T cells, and polyfunctional CD8+ T cells. The immune response to natural infection is likely to provide some degree of protective immunity even against SARS-CoV-2 variants because the CD4+ and CD8+ T cell epitopes will likely be conserved. Thus, vaccine induction of CD8+ T cells to more conserved antigens such as the nucleocapsid, rather than just to SARS-CoV-2 spike antigens, may add benefit to more rapid containment of infection as SARS-CoV-2 variants overtake the prevailing strains.

(Excerpt) Read more at ncbi.nlm.nih.gov ...


TOPICS: Business/Economy; Culture/Society; Technical
KEYWORDS: coronavirus; covid19; immunity
Here is yet again another study showing that natural immunity is real even though it is discounted by our government. Keep in mind the World Health Organization changed the definition of herd immunity:

1. 9 June 2020--"when a population is immune either through vaccination or immunity developed through previous infection"

2. 13 November 2020--"a concept used for vaccinations"

So why are definitions of medical terms being changed and everyone, regardless of having had the disease or not, must be vaccinated? And the previously infected received the entire virus, not just mRNA encoding the spike protein.

1 posted on 08/02/2021 8:20:17 PM PDT by packagingguy
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To: All

Yeah, but what about the latitudinal analysis?


2 posted on 08/02/2021 8:27:40 PM PDT by BipolarBob (To get out of this game, guys . . it looks like . . we're going to have to save Jumanji.)
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To: packagingguy

“So why...everyone, regardless of having had the disease or not, must be vaccinated?”

Because antibody level testing is far more expensive.

I ate cooked meat in early 2020. It probably had Covid from infected workers. How many antibodies I had as a result I do not know. It would be insufficient to test me for antibodies present or not.


3 posted on 08/02/2021 8:30:15 PM PDT by Brian Griffin
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To: packagingguy

Anyone FOOLISH enough to believe ANYTHING coming from the corrupt Gov’tbureaucrats deserves everything they have coming to them. My family lives if Virus Central (Florida) if you believe the gov’t and their MSM Propagandists. Not one of us to this day has been sick.
Not one co-worker we all work with has been sick. Not one family member or friend or co-workers family members have been sick.
Our youngest son, a college student is a Gamer. He and his friends hang out in large groups and attend major Gaming Events. He tells us no one he knows or has spoken to has been sick.
He also drives for Uber to earn money. Exposing himself to strangers continuously. He’s perfectly fine. And, so are we.


4 posted on 08/02/2021 8:38:25 PM PDT by ocrp1982 ( Bibicly)
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To: packagingguy

Anyone FOOLISH enough to believe ANYTHING coming from the corrupt Gov’tbureaucrats deserves everything they have coming to them. My family lives if Virus Central (Florida) if you believe the gov’t and their MSM Propagandists. Not one of us to this day has been sick.
Not one co-worker we all work with has been sick. Not one family member or friend or co-workers family members have been sick.
Our youngest son, a college student is a Gamer. He and his friends hang out in large groups and attend major Gaming Events. He tells us no one he knows or has spoken to has been sick.
He also drives for Uber to earn money. Exposing himself to strangers continuously. He’s perfectly fine. And, so are we.


5 posted on 08/02/2021 8:38:25 PM PDT by ocrp1982 ( Bibicly)
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To: Brian Griffin

SARS-CoV-2 RNA (COVID-19) and Influenza A and B, Qualitative NAAT

$511.70

https://www.questdiagnostics.com/home/Covid-19/Pricing/

I haven’t found plaque reduction neutralization test (PRNT) pricing.


6 posted on 08/02/2021 8:38:33 PM PDT by Brian Griffin
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To: packagingguy

What is “longitudinal” analysis?

Does anybody, including the author know?


7 posted on 08/02/2021 8:55:35 PM PDT by Sequoyah101 (Politicians are only marginally good at one thing, being politicians. Otherwise they are fools.)
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To: packagingguy

I will take natural immunity through infection over narrow immunity targeting only the spike protein any day of the week. It is not even a fair fight really.

As a matter of fact, it looks like the coronavirus has already adapted to defeat the insanely narrow pressure applied to it.


8 posted on 08/02/2021 9:08:22 PM PDT by walkingdead (We are sacrificing American youth's future on the altar of our own fear. And it is a travesty.)
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To: ocrp1982

Same thing here. No social distancing at work, no masks, and yet none of us got covid.

The Only person I know who got covid was vaccinated back in Jan


9 posted on 08/02/2021 9:14:54 PM PDT by roving
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To: packagingguy

So in order not to catch it you have to catch it ??? Seems kind of a worthless study to me, but I’m sure it was funded by the taxpayers so maybe the can study increased hangnail incidence in vaccinated vs infected or something equally useful.


10 posted on 08/02/2021 10:50:06 PM PDT by from occupied ga (Your government is your most dangerous enemy - EVs a solution for which there is no problem)
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To: Sequoyah101; ocrp1982

A longitudinal study is repeated observation of an experimental group over a period of time (here they were looking at people who had been infected). Their immunity apparently was robust for a long time. This has been shown in other studies as well.

I just came back from Florida last week. Left Wednesday and headed to Alabama. On my last trip to Georgia and Alabama I became ill from the coronavirus and began to feel it within 4-5 days. That was 9 months ago.

This time I feel fine even though I was in crowded places, nobody wore a mask and I have not been vaccinated. So in my study with a sample size of n=1 natural immunity seemed to have worked, if one is foolish enough to believe covid-19 is running rampant in Florida because of Ron DeSantis.


11 posted on 08/03/2021 7:29:51 AM PDT by packagingguy (Kit)
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To: packagingguy

Now I know. Thanks.


12 posted on 08/03/2021 7:55:44 AM PDT by Sequoyah101 (Politicians are only marginally good at one thing, being politicians. Otherwise they are fools.)
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