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Ivermectin docks to the SARS-CoV-2 spike receptor-binding domain attached to ACE2 [IVERMECTIN defends against the SPIKE PROTEIN from both the VIRUS and the VACCINE!!!}
Researchgate ^ | June 2020 | STEVEN LEHRER1 and PETER H. RHEINSTEIN2

Posted on 06/06/2021 2:56:32 PM PDT by Fractal Trader

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One drug that has attracted interest is the antiparasitic compound ivermectin, a macrocyclic lactone derived from the bacterium Streptomyces avermitilis. We carried out a docking study to determine if ivermectin might be able to attach to the SARS-CoV-2 spike receptor-binding domain bound with ACE2. Materials and methods: We used the program AutoDock Vina Extended to perform the docking study. Results: Ivermectin docked in the region of leucine 91 of the spike and histidine 378 of the ACE2 receptor. The binding energy of ivermectin to the spike-ACE2 complex was -18 kcal/mol and binding constant was 5.8 e-08. Conclusion: The ivermectin docking we identified may interfere with the attachment of the spike to the human cell membrane. Clinical trials now underway should determine whether ivermectin is an effective treatment for SARS-Cov2 infection.

(Excerpt) Read more at researchgate.net ...


TOPICS: Culture/Society; Extended News; News/Current Events
KEYWORDS: chinavirus; chinavirusvaccine; covid19; covid1984; dsj03; ivermectin; spikeprotein
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To: Fractal Trader

I live in Panama and found out today that Ivermectin is available OTC at our local pharmacies. But if you really want a good price, go to the pet store. They have it available, at the same dosages, for even less than at the pharmacy. Such a deal!


61 posted on 06/06/2021 5:11:20 PM PDT by OrangeHoof (Chinese communism will look different once the masks come off.)
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To: Fractal Trader

Bump


62 posted on 06/06/2021 5:13:52 PM PDT by stockpirate (Rebellion to tyranny is obedience to God., Where Justice Ends Tyranny Begins)
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To: Fractal Trader

In April I had Covid-19. I was treated with Ivermectin, antibiotics, vit C, Zinc and inhaler. 70 year old double by-pass. Had low grade fever for 2 days, thats it


63 posted on 06/06/2021 5:17:49 PM PDT by stockpirate (Rebellion to tyranny is obedience to God., Where Justice Ends Tyranny Begins)
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To: JohnBovenmyer

The dose per pound of the horse paste is the same as the dose per pound for humans. You are correct - for a 200 pound human (me) I get 6 treatments out of one tube.


64 posted on 06/06/2021 5:18:24 PM PDT by 21twelve (Ever Vigilant. Never Fearful!)
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To: OrangeHoof

Panama,
I almost made it
down there!
I’ll try my local
Pet store here
In SoCal.
Thanks!


65 posted on 06/06/2021 5:26:29 PM PDT by Big Red Badger (Be Still and Know that I Am God. Rev 19)
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To: Jane Long

Ivermectin is also supposed to protect against variants.
_____________________________________________________________

Another reason 2 more tubes of Pony Paste got picked up today with 50 lbs of laying hen pellets and 52 lbs of dog food. TSC was sold out of the lower-priced tubes. This should keep our horses from getting the Coof.

Concerning dosing:
Math is not hard ya’ll, just keep your units straight.


66 posted on 06/06/2021 5:29:17 PM PDT by JCL3 (As Richard Feynman might have said, this is reality taking precedence over public relations.)
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To: catnipman

Many thanks!


67 posted on 06/06/2021 5:34:04 PM PDT by WildHighlander57 ((WildHighlander57 returning after lurking since 2000))
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To: JCL3

I have the human pills.....so, don’t have to worry about that.

We save the tubes and liquid for the livestock :)


68 posted on 06/06/2021 5:35:53 PM PDT by Jane Long (America, Bless God....blessed be the Nation 🙏🏻🇺🇸)
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To: Titus-Maximus; grey_whiskers

Because you can’t have EUA with any available, alternative treatments.


69 posted on 06/06/2021 5:42:29 PM PDT by Jane Long (America, Bless God....blessed be the Nation 🙏🏻🇺🇸)
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To: Valpal1

That is good news. Hope you are right about that.


70 posted on 06/06/2021 5:43:25 PM PDT by firebrand ( )
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To: gitmo

Just tell your doctor you’ve got worms.


71 posted on 06/06/2021 5:49:50 PM PDT by P-Marlowe ( Freep mail me if you want to be on my Fingerstyle Acoustic Guitar Ping List )
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To: ransomnote; Valpal1

Ping to valpal1’s post:

https://freerepublic.com/focus/f-news/3965578/posts?page=32#32

“That may not be true. The mRNA is still going to instruct the cells to produce the spike proteins. Ivermectin won’t block that. After the proteins are produced, Ivermectin would bind to them, preventing them from doing anything, but that doesn’t mean the immune system won’t still recognize them as foreign and needing to be destroyed and still cause antibodies to be produced.”


72 posted on 06/06/2021 6:01:08 PM PDT by WildHighlander57 ((WildHighlander57 returning after lurking since 2000))
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To: catnipman

“typical therapeutic doses range from 12-24 grams/day”

Crap, that’s a pill larger than a walnut. Doubt I could swallow it. No wonder Fauchi has discredited Ivermectin.


73 posted on 06/06/2021 6:39:31 PM PDT by BobL (I shop at Walmart and eat at McDonald's, I just don't tell anyone, like most here.)
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To: BobL

that was a typo ...

12-24 mg


74 posted on 06/06/2021 6:51:35 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: catnipman

ivermectin horse paste is 1.87% ivermectin

-—your dosing is totally incorrect


75 posted on 06/06/2021 6:59:21 PM PDT by drSteve78 (Je suis deplorable. WE'RE NOT GOING TO TAKE IT ANYMORE)
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To: 21twelve

The dose per pound of the horse paste is the same as the dose per pound for humans. You are correct - for a 200 pound human (me) I get 6 treatments out of one tube.

———THIS IS CORRECT. Mammal dose is same for all mammals.

Unless you are a snake.


76 posted on 06/06/2021 7:01:43 PM PDT by drSteve78 (Je suis deplorable. WE'RE NOT GOING TO TAKE IT ANYMORE)
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To: Fractal Trader

And it tastes like apple paste.


77 posted on 06/06/2021 7:06:42 PM PDT by P.O.E. (Pray for America)
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To: catnipman

Ignore cantnipman’s suggestions for dosing. They are entirely wrong, by a factor of 1000. He has confused milligrams with grams.

Charlie the Clinical Pharmacist

Below link will give you the correct dosing.

https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-I-MASK-Protocol-v4-2020-11-22.pdf


78 posted on 06/06/2021 7:27:32 PM PDT by cpdiii (Texan Coonass Cane Cutter Deckhand Roughneck Geologist Pilot Phamacist & much more education)
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To: drSteve78

Before I first medicated myself I reviewed 4 or 5 articles from various sources, did the math two different ways and triple-checked the numbers!


79 posted on 06/06/2021 7:33:16 PM PDT by 21twelve (Ever Vigilant. Never Fearful!)
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To: libh8er

I have read that ivermectin prevents the mrna of viruses to be inactivated in the cytoplasm of the infected cells by keeping the mrna from being “read” by the protein making machinery.. I am too lazy to give you the quotation exactly...but it was in a reputable journal.
Time and testing will tell.


80 posted on 06/06/2021 7:46:33 PM PDT by Getready (Wisdom is more valuable than gold and diamonds, and harder to find.)
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