Posted on 05/14/2021 12:55:25 PM PDT by Treeless Branch
The moment many transplant patients and physicians have been waiting for has finally arrived, but unfortunately the news is not great. We have now published in JAMA second-dose data from our national study of vaccine immune responses in immunosuppressed solid organ transplant recipients. Among 658 COVID-19-naïve participants who received the full two-dose series of mRNA vaccines, 46% (compared to 83% after just one dose) still had no detectable antibodies, and even among those with detectable antibodies, the levels were still somewhat low. The situation is worse among those taking anti-metabolites: for this group, 57% had no antibodies after full vaccination, compared to 32% with no antibodies...
(Excerpt) Read more at medpagetoday.com ...
“Are the immunosuppressed responding to vaccines?”
How could they?
No surprises here. Immunocompromised individuals are very susceptible to communicable diseases. It is the nature of the beast. Transplant recipients take medications to inhibit antibodies in an effort to thwart rejection of the transplanted organ.
I suspect people who have had organ transplants and are on immunosuppressive therapies already know that vaccines might be ineffective for them. Regeneron’s REGEN-COV therapy MAY be effective as a prophylactic or treatment in immunocompromised patients. There are probably other options, but best to discuss that with their MD and know their options in advance.
Whether forcing an immune system that's already insufficient to work even harder is a good idea, heaven only knows.
Many people have "Selective IgA Deficiency" and it often does not present any symptoms (my immunologist discovered a couple years ago that I have zero IgA). I wonder if Selective IgA Deficiency people would fall into the class of people described in the article.
I found this paper on Selective IgA Deficiency and COVID:
IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection
By Isabella Quinti , Eva Piano Mortari, Ane Fernandez Salinas, Cinzia Milito, Rita Carsetti
Published: 6 April 2021 by Frontiers Media SA
Frontiers in Cellular and Infection Microbiology , Volume 11
doi:10.3389/fcimb.2021.655896Abstract: A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It protects the epithelial barriers from pathogens and modulates excessive immune responses in inflammatory diseases. An early SARS-CoV-2 specific humoral response is dominated by IgA antibodies responses greatly contributing to virus neutralization. The lack of anti-SARS-Cov-2 IgA and secretory IgA (sIgA) might represent a possible cause of COVID-19 severity, vaccine failure, and possible cause of prolonged viral shedding in patients with Primary Antibody Deficiencies, including patients with Selective IgA Deficiency. Differently from other primary antibody deficiency entities, Selective IgA Deficiency occurs in the vast majority of patients as an asymptomatic condition, and it is often an unrecognized, studies are needed to clarify the open questions raised by possible consequences of a lack of an IgA response to SARS-CoV-2.
Wouldn’t the nano particles that go into each cell from mRNA shots kill them the same way they are going to kill every other person who went along with the sheep and became a guinea pig. You’d have to be retarded to put something that goes through your cells after just 6 months of testing.
I’d like to see some data on people over 80 as well.
I have a close friend who sent me the article who had a transplant. His doctor sent him this article to notify him that the vaccine had had taken two months ago might not have worked. Friend had just taken first vacation in a year after feeling safe from the vaccine. Doctor said he had four other vaccinated patients in the hospital with Covid.
My brother of a liver transplant patient, third year. He has had both shots of moderna. Felt ill within hours of 2nd shot, but his transplant team felt he should at least try. Was better the next day. He’s had one set of bloodwork since shot and little to no antibodies yet. Scheduled for another check up later this month.
“How could they?”
Good point.
Yet they actually are responding, some better than others.
But of course you are right. You take drugs that suppress the immune system, you won’t respond to vaccination as robustly.
Well I recall reading something to the effect that vaccines, while purported (reported) to be 95% effective, are actually only 60% or so effective in those above the age of 80. Other freepers confirmed that this is generally true. Immuno-compromised can mean different things depends on how you define it. Taking medicine, diagnosed condition, age could all be factors.
There is a curiosity with numbers of public figures (e.g. many members of the Yankees staff, Bill Maher etc) who are fully vaccinated who test positive. But, I suppose that is to be expected as the vaccines don’t promise you won’t get infected, they just promise to reduce likelihood of severity if you are. Hard to know what the upshot on all this really is.
Our family all took the shots because of My brothers transplant. He lives in the country and stays away from large groups. Basically a pod of people of about 10 people. He got the shots but not much immunity.
I get infusions that kill all my B cells. My doctor told me plainly that the vax won’t work for me. It needs B cells to attach to.
Immunosuppression, as I understand it, isn’t an all or nothing state. Immunity can be somewhat impaired, or nearly totally impaired. If the impairment is great, the response to a vaccine should be minimal. Otherwise, as you note, less so.
That’s right.
Often the body rejects a transplant despite the best efforts toward immunosuppression.
Not again. Not ever again. At this point, if they don't work, then we get to herd immunity that much faster.
If you're immunosuppressed stay the hell home permanently.
High risk should still continue to mask and avoid crowds per CDC. High risk are those over 80, those over 65 with multiple pre existing conditions, and those who are immunosupressed (IE HIV patients, those on immunosupressing drugs). But these people are also threatened by garden variety influenza, and even common colds can throw them for a loop.
And this should have been THE standard the ENTIRE time instead of the immoral and unreasonable lock downs.
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