That was very wordy.
Here’s where, hidden within all of your words, you are missing the boat.
I already know how mRNA works to provide a “recipe” normally “written from DNA” to ribosomes that “do the cooking” and produce the specific protein. I also am aware of the challenges faced over the past few decades with encapsulating the mRNA in a lipid (fat) envelope to prevent the immune system from destroying the alien mRNA on sight.
You see, I learned these things, more or less, from a rather well known Hungarian biochemist named Katalin Kariko (who just happens to be a Senior Vice President at BioNTech.
You see, this immune response is triggered when (B-cells, I think) encounter pieces of mRNA that don’t belong. The lipid enveloping the injected, modified mRNA acts as a sort of “disguise” that allows it to slip past your natural immune response long enough to program the ribosome to produce the needed protein, in this particular case, it is supposed to create a “spike protein” which, as you say, is a pretty identifiable part of the coronavirus, in fact, it is the possession of these spike proteins that give coronavirus’ their name.
This particular protein is not natural to humans. As you also correctly state, the usual process is derived from copying the individuals DNA to produce a protein that the DNA specifies. The DNA does not have this spike protein in its recipe book, and that is why the modified mRNA has to be injected in the first place, and why it has to be hidden from your immune system long enough to do its job.
The bigger purpose, of course, is to release enough of the newly created spike proteins to “train” your immune system to recognize and attack them as an invader in the event that they are encountered as part of the coronavirus itself.
The idea of having your own ribosomes create the spike protein, instead of using traditional immunization methods involving inactivated viral cells or some other training material, is to eliminate any risk of actually infecting a person unintentionally with a live virus. It’s actually a pretty brilliant theory.
My issue here, is simply that nobody knows exactly how well the spike protein itself will work in programming the immune system to respond to a viral infection that it has never been exposed to, and the fact that nobody knows how well the immune system will be able to differentiate between this protein and many other naturally occurring proteins within the body.
We don’t know the risks. Autoimmune diseases are a real threat, and, despite the politically sensitive nature of the statement, not all people are alike.
If you have managed to follow so far, maybe you’ll be the first to “get” this as well. In spite of the “experts” and “physicians who swooped down from their lofty perches to set me straight on this, the genetic material (mRNA) that’s being modified in order to coax your ribosomes into creating a spike protein that would not be created any other way, is intended to MODIFY your immune system response, and the intent is that this modification will be persistent. (That your immune system will permanently respond to a protein identified as a spike protein, by attacking it.)
You, and others here don’t approve of the term genetic modification that I have used in reference to this, but not one, no matter how long and wordy the response, has even attempted to refute the fact that this “vaccine” operates by using genetic material in an attempt to permanently change the way your immune system responds to a protein that is identifies as a spike protein, is, and can certainly be referred to as a genetic modification.
Once this change is made, there’s no undoing it.
Thank you, however for taking the time to sanctimoniously explain to me things that I already know.
-Hugh
That’s a beautiful post.
They cannot refute it. No one needs a PhD in virology or an MD to make decisions about their personal healthcare - but the public does need adequate information to give informed consent. The only person liable for medical damage with this is the patient himself. No one can claim that we won’t all suffer in particular from autoimmune disorders after this unnecessary vaccine.
I think the voices sounding the alarm and risking their careers are heroic. The “shaddup and get yer jab, stupid” bullies have some vested interest like $$$.
Thanks for your posts, Hugh.
The immune system wouldn't trigger off just some random mRNA floating around. That's not the issue or why the lipid shell is required. The lipid shell enables a transport mechanism across cell membranes. Otherwise the mRNA has no way into the cellular cytoplasm where the ribosomes are. It would simply float around outside your cells rapidly degrading.
"You see, this immune response is triggered when (B-cells, I think) encounter pieces of mRNA that don’t belong.
No, the immune response begins when macrophages, neutrophils, and NK T-cells encounter the foreign protein produced. The mRNA has nothing to do with the immune response. And B-cells don't come into play until after dendritic cells have taken samples of the protein to lymph nodes and activated virgin T-cells.
"The lipid enveloping the injected, modified mRNA acts as a sort of “disguise” that allows it to slip past your natural immune response long enough to program the ribosome to produce the needed protein"
No, the lipid shell enables the mRNA to gain access to cellular cytoplasm. And the mRNA doesn't "program" the ribosomes. The entire function of ribosomes is to attach to mRNA and produce what's encoded. There's no "programming"; they simply follow along the string of nucleotides, reading what's there and creating the corresponding product. The ribosome remains unchanged throughout this process. The word "programming" implies an alteration, which doesn't - and can't - happen.
"The idea of having your own ribosomes create the spike protein, instead of using traditional immunization methods involving inactivated viral cells or some other training material, is to eliminate any risk of actually infecting a person unintentionally with a live virus."
Gen 2 (Subunit, recombinant, polysaccharide, and conjugate) vaccines like Hep B, HPV, Pertussis (Whooping cough), etc. already solved that particular problem decades ago. The immune trigger is attached to something inert or otherwise non-infectious and dropped into the body. Immune system sees the trigger, attacks it, samples it, generates T-cell and B-cell responses, antibodies, etc.
"My issue here, is simply that nobody knows exactly how well the spike protein itself will work in programming the immune system to respond to a viral infection that it has never been exposed to, and the fact that nobody knows how well the immune system will be able to differentiate between this protein and many other naturally occurring proteins within the body."
It works the same as being exposed to the virus. We know this because it was tested for a long time. The immune system triggers off multiple points that identify the virus as foreign, primarily relating to various folded aspects of the S protein. Whether that S protein is attached to a SARS-CoV-2 virion or a different virus or a human cell doesn't particularly matter. We learned that with the gen 2 vaccines. You can attach that protein to ANYTHING and the immune response kicks in and does its job the same as if it were on the original virus.
There's no real difference in the methodology of gen 2 vs gen 3 vaccines in terms of immune response trigger. We know gen 3 works because it's worked for decades with gen 2. You present the immune system trigger, you get T-cell and B-cell response including antibodies. This creates lasting immunity. It's been tested in gen 2 products and it's been tested in gen 3 products. It works. The body doesn't know the difference, except you prevent the massive disease damage and risk of death that comes from an actual infection.
"You, and others here don’t approve of the term genetic modification that I have used in reference to this, but not one, no matter how long and wordy the response, has even attempted to refute the fact that this “vaccine” operates by using genetic material in an attempt to permanently change the way your immune system responds to a protein that is identifies as a spike protein, is, and can certainly be referred to as a genetic modification."
It works the same way gen 2 vaccines do. Triggering an immune system response with a foreign protein is NOT "genetic modification". It's not even remotely related to genetic modification. Genetic refers to genes. Genes are in DNA. No DNA is modified. No genetic modification is occurring.