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Convalescent plasma is ineffective for covid-19
British Medical Journal ^ | 10/22/2020 | Elizabeth B Pathak

Posted on 10/23/2020 5:56:46 PM PDT by catnipman

Convalescent plasma generated great enthusiasm in the earliest days of the coronavirus disease

The PLACID Trial was a rigorous randomized controlled study on a topic of enormous global importance

In prespecified, intention-to-treat analyses, the PLACID Trial investigators found no net benefit associated with convalescent plasma in patients admitted to hospital with moderate covid-19

there was no net clinical benefit to patients

(Excerpt) Read more at bmj.com ...


TOPICS: Culture/Society; Front Page News; News/Current Events
KEYWORDS: bloodplasma; chinavirustreatment; coivd; convalescent; covid19; plasma
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To: catnipman

https://www.centerforbiosimilars.com/view/fauci-discusses-experimental-covid19-drugs-and-school-openings


21 posted on 10/23/2020 7:05:01 PM PDT by Sacajaweau
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To: Sacajaweau

The above by Fauci covers everything....August


22 posted on 10/23/2020 7:05:36 PM PDT by Sacajaweau
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To: SecAmndmt

Thanks for the link to the Senate hearing. I watched Dr. Kory’s presentation — wow, is he energetic and passionate. This hearing was back in May 2020. Here we are five months later and we still don’t seem to hear much about the MATH+ and EVMS critical care protocols. Dr. Kory said the protocols were sent to the White House four times and Sen. Ron Johnson said that he sent it to Mark Meadows. Yet they haven’t seem to have risen to the top of critical care for COVID.


23 posted on 10/23/2020 7:10:34 PM PDT by ProtectOurFreedom ("Inside Every Progressive Is A Totalitarian Screaming To Get Out" -- David Horowitz)
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To: ProtectOurFreedom

I’ve seen several.


24 posted on 10/23/2020 7:37:27 PM PDT by neverevergiveup
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To: ProtectOurFreedom

“. It’s curious that neither HCQ or Ivermectin is part of the MATH+ protocol”

HCQ is an ionophore, primarily a transport mechanism for zinc. Zinc prevents RNA virus replication, so presumably once the body is full of viral material, HCQ is not the focus.

The “plus” in MATH+ can include zinc and other components.

The “A” in MATH+ is IV ascorbic acid (an antiviral at high doses).

Dr Brownstein uses nebulized peroxide, saline or Lugol’s for those with heavy lung congestion...arguably “disinfecting” the lungs.


25 posted on 10/23/2020 7:40:15 PM PDT by SecAmndmt (Arm yourselves!)
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To: ProtectOurFreedom

The answer as to why President Trump cannot openly promote integrative type therapies for treatment...Pharma would sink his re-election campaign, guaranteed.

Look for him to introduce this therapy once he is re-elected.

Understand that zinc + HCQ and MATH+ therapy could cost big Pharma BILLIONS in lost revenue...the case for vaccines is greatly reduced simply by treating ALL viral infections with MATH+ therapy.


26 posted on 10/23/2020 7:46:18 PM PDT by SecAmndmt (Arm yourselves!)
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To: SecAmndmt

Excellent insights. Thanks for pointing that out. Everything points to what you stated as being true, especially the behavior and statements of Fauci and Birx.


27 posted on 10/23/2020 7:54:49 PM PDT by ProtectOurFreedom ("Inside Every Progressive Is A Totalitarian Screaming To Get Out" -- David Horowitz)
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To: Sacajaweau

“I believe Fauci supported this 100%”

actually, he was quite opposed to it,and for very good reasons: plasma contains a massive number of other components besides just the covid antibodies, and thus has a MUCH larger likelihood of causing quite a few unpleasant and/or damaging side-effects compared to pure (semi-synthetic) covid monoclonal antibodies ...


28 posted on 10/23/2020 9:21:34 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: Jim Noble

“It was a good idea, but there is no way to make sense out of this “trial” since we do not know who got what in terms of neutralizing antibody.”

just as there would be no reasonable way to perform a quantitative assay of said antibodies on each and every unit of donated plasma ...


29 posted on 10/23/2020 9:23:35 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: Blood of Tyrants

“but it may still make you immune.”

aside from an actual vaccine, pure, semi-synthetic covid monoclonal antibodies would be a WAY better way to go than plasma, which contains a massive number of other components besides covid antibodies ...


30 posted on 10/23/2020 9:25:44 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: ZOOKER

“Would whole blood have been better? As opposed to plasma, which has the platelets filtered out.”

that would likely be worse, way worse, because the last thing covid patients need are MORE platelets, because one of the common modes of death with covid is hypercoagulation ...


31 posted on 10/23/2020 9:27:51 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: ProtectOurFreedom

“I thought there were extremely few confirmed cases of a “cured” patient subsequently getting re-infected. Like a handful of confirmed cases.”

that’s actually true: only a handful out of millions of recoveries ...


32 posted on 10/23/2020 9:29:30 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: Dave Wright

“This would not occur in monoclonal antibody therapies like Regeneron that are manufactured and do not contain all the other proteins in natural human plasma.”

absolutely ... plus plasma has a very large number of other, non-covid components that can potentially cause all kinds of mischief ...

as far as i’m concerned, pure, semi-synthetic, standardized measures of monoclonal antibodies are going to be FAR safer and FAR more effective than whole, convalescent plasma obtained from random strangers ...


33 posted on 10/23/2020 9:33:13 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: SecAmndmt

Understand that zinc + HCQ and MATH+ therapy could cost big Pharma BILLIONS in lost revenue...


I don’t understand why lost revenue of all the other sectors of the economy means nothing (and they are suffering immensely) and only Big Pharma counts.


34 posted on 10/23/2020 11:41:13 PM PDT by Czech_Occidentalist
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To: ProtectOurFreedom

ProtectOurFreedom wrote:

“It’s interesting that video of the Houston doctor is dated April 17, 2020. It’s curious that neither HCQ or Ivermectin is part of the MATH+ protocol. Heparin is the blood thinner / anti-coagulant.

Many thanks for the info!


35 posted on 10/24/2020 2:43:02 AM PDT by WildHighlander57 ((WildHighlander57 returning after lurking since 2000)
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To: steve86

#6. I love it when people with medical knowledge “talk dirty”.

Next time, please try good old street English for us laypeople. I’m having a hard enough time with my Ebonics lessons.


36 posted on 10/24/2020 2:45:27 AM PDT by MadMax, the Grinning Reaper
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To: catnipman

Two of my family members received this treatment as part of a study. 48 hour recovery. Both were not yet admitted to the hospital - but were on the verge of being admitted. It may be that if you are already hospitalized it is not effective.


37 posted on 10/24/2020 2:47:38 AM PDT by mad_as_he$$ (Why can't we just get into the running car?)
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To: catnipman

I pretty much ignore any article telling us how something doesn’t work. More interested in those that show some promise - like Regeneron - and HCQ :-)


38 posted on 10/24/2020 4:51:09 AM PDT by trebb (Don't howl about illegal leeches, or Trump in general, while not donating to FR - it's hypocritical.)
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To: catnipman

From the same bunch that implicated MMR vaccines in autism risk.


39 posted on 10/24/2020 6:06:06 AM PDT by Arm_Bears (Hey, Rocky--Watch me pull a rabbit out of my hat!)
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To: catnipman

I’m not very enthused with any treatment in a hospital and wouldn’t want to trade a home for it.


40 posted on 10/24/2020 6:31:30 AM PDT by familyop ("Who built the cages, Joe?" --President Trump)
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