Overall, 2,541 consecutive patients were included in the analyses with a median age of 64 years (IQR: 53–76 years), 51% male, 56% African American, median inpatient LOS was 6 days (IQR: 4–10 days). The median time to follow-up was 28.5 days (IQR 3–53). The majority of patients (52%, n = 1,250) had BMI ≥ 30. Additional underlying comorbidities are detailed in Table 1. On the day of admission, two variables predicting severity of disease and mortality, highest mSOFA score and lowest O2 saturation, were recorded. However, 25% of the population did not have mSOFA scores available, as recording of this metric became institutional standard one month after the index admission. Other indicators of severity were ICU admission and mechanical ventilation status. All baseline characteristics were further stratified by the four treatment groups (hydroxychloroquine alone, hydroxychloroquine + azithromycin, azithromycin alone, and neither treatment). Median time (IQR) from admission to receipt of hydroxychloroquine was 1 day (1–2). Overall crude mortality rates were 18.1% in the entire cohort, 13.5% in the hydroxychloroquine alone group, 20.1% among those receiving hydroxychloroquine + azithromycin, 22.4% among the azithromycin alone group, and 26.4% for neither drug (p < 0.001). Adjunct therapy with corticosteroids (methylprednisolone and/or prednisone) and anti-IL-6 tocilizumab was provided in 68% and 4.5% of patients, respectively.
The above was linked to from the original article posted:
"A spoonful of (whatever) makes the HCQ go down . . ."
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