Most promising treatment so far [for COVID-19] (Synairgen SNG001, Interferon-Beta)

YouTube ^ | July 21, 2020 | Dr. John Campbell

[ProtectOurFreedom]

Dr. Campbell's synopsis of his YouTube video about Synairgen SNG001:

Interferon-Beta

• Naturally occurring antiviral protein
• Cytokine
• Interfere swith viral replication
• Induces fever and muscle pains (along with other cytokines)
• Activates immune cells, natural killer (NK) cells and macrophages
• Reduces protein synthesis in adjacent cells
• Activates an enzyme to destroy RNA, further reducing protein synthesis
• Stimulates many other interferon-stimulated genes
• Stimulates infected cells into apoptosis (cell "suicide" death)
• Key component of human immune defence against viral infection

Phase 2 study

• Inhaled interferon-beta gives high local concentrations
• Placebo controlled
• n = 101 hospitalised patients at 9 UK hospitals
• All patients tested positive for SARS-CoV-2
• Co-morbidities:
  1. Diabetics: Treatment group n = 9; Placebo group n = 3
  2. Cardiovascular disease: Treatment group n = 5; Placebo group n = 8
• Now recruiting patients ill with COVID-19 in the community

Results

• 79% reduction in risk of developing severe disease requiring ventilation or resulting in death during the treatment period
• Day one to day 16
• This difference was also noted to day 28
• Patients who received SNG001 were more than twice as likely to recover
• Defined as ‘no limitation of activities’ or ‘no clinical or virological evidence of infection’
• Measure of breathlessness, markedly reduced
• In patients with more severe disease at time of admission, SNG001 increased the likelihood of hospital discharge during the study. Six days versus nine days for those receiving placebo (not significant difference)
• More than twice as likely to have recovered by the end of the treatment period (strong trend)

Safety

• No deaths in the SNG001 group
• 6% died after being randomised to placebo
• Professor Tom Wilkinson, Trial chief investigator and Professor of Respiratory Medicine, University of Southampton: "Huge potential to restore the lung’s immune response, enhance protection, accelerate recovery, and counter the impact of SARS-CoV-2 virus."
• Professor Stephen Holgate, Medical Research Council, Clinical Professor of Immunopharmacology at the University of Southampton: "Restores the lung’s ability to neutralise the virus or any mutation of the virus or co-infection with another respiratory virus such as influenza."
• Relationship with dexamethasone and remdesivir
• Study did not include patients requiring ventilatory support

[ProtectOurFreedom]

In his video, Dr. Campbell does a good job explaining how Interferon works. To my non-medical eye, this looks very promising. He says that the inhalation delivers the medication directly to the epithelial cells needing it. Here are links from the YouTube story.

PharmaTimes: Synairgen's SNG001 shows strong promise in COVID-19 trial

Science Media Centre: JULY 20, 2020 expert reaction to announcement by Synairgen that their drug SNG001 has had positive results in initial trials on COVID-19 patients

Here are some other links:

Synairgen: COVID-19 – SG016 Clinical Trial Data Readout

Previous FR story posted by SeekAndFind: Protein Trial Results Suggest a Possible Breakthrough Treatment for COVID-19 Patients, Epoch Times, July 21, 2020.

CDC 2004: Interferon-β 1a and SARS Coronavirus Replication. Emerging Infectious Diseases, SARS Edition, Volume 10, Number 2, February 2004. It's interesting that Interferon-β was being looked at 16 years ago to fight SARS Coronavirus.

[ProtectOurFreedom]

Ping

[Mr Ramsbotham]

Sounds like it might be a good treatment for cancer.

[ProtectOurFreedom]

That’s a great idea. Somebody should get right on that.

[Grampa Dave]

About time they found a disease where the old basic interferons work.

[dljordan]

“Sounds like it might be a good treatment for cancer.”

I was on Interferon and Ribavarin for Hep-C. It was hell. I’ve never been so sick in my life.

[SeekAndFind]

RE: ( Synairgen SNG001, Interferon-Beta)

Some questions:

1) At what stage of Covid-19 is it effective for?

2) How much does it cost for the entire treatment ?

3) Is it monopolized by one company, or readily manufactured by others?

[maddog55]

Most promising treatment so far for COVID-19... herd immunity.

It’s that simple.

[EEGator]

Yep.

[bitt]

p

[Walrus]

Haven’t we caught on, yet? These daily reports of “promising” new treatments and therapies are just another ploy to keep us believing that the end is in sight, if only we follow instructions for a while longer, like until November 3rd.

[Hostage]

The preventioin and early cure has been with us for months now but because Trump promoted it, the news liars have branded it as poison that kills ….

The Key to Defeating COVID-19 Already Exists. We Need to Start Using It | Opinion from Yale University Epidemiologist

https://www.newsweek.com/key-defeating-covid-19-already-exists-we-need-start-using-it-opinion-1519535

THE CURE WILL KILL YOU!
http://www.freerepublic.com/focus/chat/3867663/posts?page=37#37

[Trump Girl Kit Cat]

It already is in trials for cancer!!

[aimhigh]

Cost?

[faucetman]

“Haven’t we caught on, yet? These daily reports of “promising” new treatments and therapies are just another ploy to keep us believing that the end is in sight, if only we follow instructions for a while longer, like until November 3rd.”

“promising” new treatments and therapies...

Where the hell have they been? This didn’t start YESTERDAY!

Like saying at this point... We’re “developing” strategies .... “developing”?

[Mr Ramsbotham]

Not surprising!

[Almondjoy]

Until the next fall when we don’t have the anti bodies and we can all catch it again. Just like the cold, the flu, and all that stuff.