To: RummyChick
18 posted on
06/19/2020 9:02:23 AM PDT by
RummyChick
(https://www.youtube.com/watch?v=nYXYfdsaHxg)
To: RummyChick
Here, we demonstrate for the first time that HNPs inhibit the proteolytic cleavage of peptidyl VWF73 and multimeric von Willebrand factor (VWF) by ADAMTS13 in a concentration-dependent manner. This inhibitory effect appears to be mediated by tight binding between HNPs and the VWF-A2 domain, which presumably competes for binding of ADAMTS13 to VWF and renders it resistant to proteolysis. Plasma levels of HNPs1-3 or HNP1, HNP2, and HNP3 are all markedly increased in patients with acquired autoimmune TTP who have severe deficiency of plasma ADAMTS13 activity. Together, our findings demonstrate a novel biological function of HNPs1-3, and suggest a potential link between inflammation, neutrophil activation, and microvascular thrombosis in TTP and possibly other inflammation-associated thrombotic disorders.
19 posted on
06/19/2020 9:04:47 AM PDT by
RummyChick
(https://www.youtube.com/watch?v=nYXYfdsaHxg)
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