Posted on 04/25/2020 9:38:17 PM PDT by SeekAndFind
A potential antiviral drug for the coronavirus has reportedly failed in its first randomised clinical trial.
There had been widespread hope that remdesivir could treat Covid-19.
But a Chinese trial showed that the drug had not been successful, according to draft documents accidentally published by the World Health Organization.
The drug did not improve patients' condition or reduce the pathogen's presence in the bloodstream, it said.
What do we know about the study? News of the failed trial spread after the WHO posted details on its clinical trials database, before it was removed. The WHO has since confirmed the draft report was mistakenly uploaded.
It showed that researchers studied 237 patients, administering the drug to 158 and comparing their progress with the remaining 79, who received a placebo.
After a month, 13.9% of the patients taking the drug had died compared to 12.8% of those receiving the placebo. The trial was stopped early because of side-effects.
"Remdesivir was not associated with clinical or virological benefits," the summary states.
All three main US stock indexes fell back from gains of over 1% after the news broke over the trial.
(Excerpt) Read more at bbc.com ...
GILEAD SCIENCES RESPONDS TO W.H.O:
Gilead has disputed the WHO post.
“We believe the post included inappropriate characterisations of the study,” a spokesman for Gilead said, adding that it was terminated early due to low enrolment and was therefore not statistically meaningful.
“As such, the study results are inconclusive, though trends in the data suggest a potential benefit for remdesivir, particularly among patients treated early in disease,” he said.
This does not spell the end of the road for the drug, however, and several continuing trials will soon provide a clearer picture on the drug’s use.
It could actually be successful in China and they would hide this fact.
But a Chinese trial showed that the drug had not been successful, according to draft documents accidentally published by the World Health Organization. …Stopped reading at that point.
What's not to trust?
This is not accurate but widely repeated. Patients were not treated until 12 days and then many pulled out of the test. This is more WHO crap.
Evercore ISI analyst Umer Raffat pointed out in a note to clients, though, the study allowed patients to start the Gilead candidate up to 12 days after symptoms first appeared. “That is a VERY long window,” he wrote, noting that with antivirals for acute infection, “the earlier you start, the better the efficacy.”
“For me, the real detail is NOT out yet: efficacy in patients that start early,” he said.
Gilead, for its part, also took issue with idea that the trial had failed. “We believe the post included inappropriate characterizations of the study,” said Gilead Chief Medical Officer Merdad Parsey, M.D., Ph.D., in a statement. “The study was terminated early due to low enrollment, and, as a result, it was underpowered to enable statistically meaningful conclusions.”
While the results are inconclusive, though, Gilead did see “trends in the data [that] suggest a potential benefit for remdesivir, particularly among patients treated early in disease,” Parsey said.
Another day, another leak—or so it seems for Gilead Sciences’ COVID-19 hopeful remdesivir. This time, the World Health Organization (WHO) accidentally revealed data from a study in China showing that the treatment neither improved patients’ condition nor tamped down on the amount of virus in their blood, the Financial Times reported, calling the trial a “flop.”
But was it really a flop? Analysts are saying no.
The study tested remdesivir in 158 patients, comparing their response to 79 patients in a control group. The treatment “was not associated with a difference in time to clinical improvement,” according to draft documents inadvertently published by the WHO that were seen by the FT and Stat and have since been removed. Patients in both study arms experienced side effects at roughly the same rate (about 65%), but more patients on remdesivir stopped treatment early because of side effects compared with placebo (12% versus 5.1%).
I have no problem believing that it isn’t effective. However, I would NEVER judge the efficacy of an American drug on the basis of a Chinese trial. I wouldn’t trust China in ANY context. They are a wannabe nation and would/will do ANYTHING to embellish their stature. There are lots of wonderful Chinese people. There are also a lot of nationalistic brainwashed disciples of the CCP. Beware.
Hm. Maybe just needs better testing.
accidentally,yeh right. Seems like the WHO is prepared to torpedo any treatment not out of China.
Might be a dishonest tactic by China to drive down the bidding for the patent on the drug
Which China ( Wuhan Lab) applied for on 21 January.
The day after the dishonest sob’s admitted the virus to be human transmitted
Nice find! Thanks for the link.
What an even more disgusting country than even I thought they were.
Bitter enemies, China and WHO and dems who side with them and msm that does. Which is most.
A more despicable lot you will not find.
If you were a Red Chinese official on the coronavirus fiasco coverup, would you want a “CURE” to be found, or would you want the disease to continue to rage the industrial nations of the world (screw the 3rd world countries - they don’t count anymore)?
In the case of the BBC (British Bowing Communists), never trust them. They have become the CBS/CNN/MSNBC of British news (and have been anti-American for a long time, though not as long as Reuters.
Gonna be HCQ + Z pac + zinc
Take that Fauci, and stuff that were the “clinical trials” don’t shine.
CPT Clay wrote:
Gonna be HCQ + Z pac + zinc
Yep.
Some links:
https://www.freerepublic.com/focus/news/3838896/posts?page=39#39
https://www.freerepublic.com/focus/news/3838819/posts?page=95#95
https://www.freerepublic.com/focus/news/3838819/posts?page=135#135
We should all start referring to it as: Zinc, along with HCQ, with a Z pac.
It is zinc that is the primary ingredient in the trio. Intercellular zinc is what stops the virus replicase.
I would believe Gilead or any US private sector drug laboratory on any treatment over any government agency , especially the Chinese!!!
This is very clear- the government agencies do not want treatments to be known to work
This is because they want everybody to line up and get their vaccine shot for 100 bucks down the road
Vaccines are giant money makers , because they get healthy people to take them voluntarily
You’re not in a hospital bed dying you’re perfectly healthy and your doctor says “here I really recommend this!”
It’s entirely profit driven and is entirely opposite to the Hippocratic oath
“First, do no harm”
BEIJING (AP) — Scientists in the city at the center of China’s virus outbreak have applied to patent a drug made by U.S. company Gilead Science Inc. to treat the disease, possibly fueling conflict over technology policy that helped trigger Washington’s tariff war with Beijing.
“This is very clear- the government agencies do not want treatments to be known to work”
____________________________________________________________________________
That is exactly right. We just had the HHS and FBI pull off a SWAT Team raid on a clinic in Michigan that was using IV Vitamin C.
IV vitamin c has a well documented successful track record going back over 50 years. It is at this minute being used by Board Certified doctors around the world to treat COVID 19. It is saving lives yet this information is being scrubbed from social media especially on Facebook.
This is the last thing Fauci and his criminal gang want you to know.
https://www.sciencedirect.com/science/article/pii/S2213434420300153
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