Posted on 04/24/2020 1:14:42 PM PDT by ProtectOurFreedom
A Randomized Clinical Trial
Findings In this phase IIb randomized clinical trial of 81 patients with COVID-19, an unplanned interim analysis recommended by an independent data safety and monitoring board found that a higher dosage of chloroquine diphosphate for 10 days was associated with more toxic effects and lethality, particularly affecting QTc interval prolongation. The limited sample size did not allow the study to show any benefit overall regarding treatment efficacy.
Meaning The preliminary findings from the CloroCovid-19 trial suggest that higher dosage of chloroquine should not be recommended for the treatment of severe COVID-19, especially among patients also receiving azithromycin and oseltamivir, because of safety concerns regarding QTc interval prolongation and increased lethality.
Main Outcomes and Measures Primary outcome was reduction in lethality by at least 50% in the high-dosage group compared with the low-dosage group. Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. Secondary end points included participant clinical status, laboratory examinations, and electrocardiogram results. Outcomes will be presented to day 28. Viral respiratory secretion RNA detection was performed on days 0 and 4.
(Excerpt) Read more at jamanetwork.com ...
The whole point of the treatment of plaqinel is to get the zinc into the cell. I dont get these studies without adding zinc.
From your link:
“There are only a few places left in the world where
chloroquine is still effective including parts of
Central America and the Caribbean.”
Also, see:
Information for International Travel
Third column.
https://www.cdc.gov/malaria/travelers/country_table/b.html
So if you wanted to discount the faux study why not start with an explanation, instead of running the entire negative up the flag poll before trying to point to any disagreement you might have with the report? You don’t see anything wrong with recommending that HCQ be used ONLY in a hospital setting, as you opined on another thread. Confusion is the tool of the globalist agenda. Don’t help them
According to Multiverse Theory somewhere this is all vary funny.
Chloroquinine has a side effect of haemolytic anaemia with some men of African or Mediterranean descent due to a mutation on the Y chromosome. HCQ avoids this problem. For women either medicine is OK.
5. Manson P, Cooke G, Zumla A, eds. (2009). Manson's tropical diseases (22nd ed.). [Edinburgh]: Saunders. p. 1240. ISBN 978-1-4160-4470-3. Archived from the original on 2 November 2018. Retrieved 9 September 2017.
6. Bhattacharjee M (2016). Chemistry of Antibiotics and Related Drugs. Springer. p. 184. ISBN 978-3-319-40746-3. Archived from the original on 1 November 2018. Retrieved 9 September 2017.
7. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06.
No completely. The anti-infalammatory effect of HCQ is why it is used with RA and Lupus, and now covid-19 patients. By reducing inflammation the body has a better chance to fight virus. By ferrying ZINC into the infected cells, the reduction in viral load is enabled. So HCQ has a dual action, a dual efficacy.
Yep!!
Listened to it.
Excellent interview!
Because the way FR is structured, you put the article first, then secondly you add your own personal comments. It’s always been that way. I follow the rules in that regard.
I DID highlight in bold and red the negatives in the directly quoted study excerpt I provided.
Thanks for that. I was just searching for advice on when to use Chloroquine and when to use HCQ. Wiki says “Hydroxychloroquine has similar pharmacokinetics to chloroquine”
HCQ is a by mouth form and the form used by these ‘researchers’ is IV.
You picked up on one negative unrelated(Not about safety) statement and ignore all the parts about how it is generally safe.
That’s the main reason that hydrocloroquine is used because of the lesser frequency of prolonged QT or heart problems
The interventions tested in this study were based on different regimens using CQ base 150 mg tablets (241.9 mg of the phosphate CQ per tablet) (Farmanguinhos). Eligible participants were allocated at a 1:1 ratio to receive orally (or via nasogastric tube in case of orotracheal intubation) either high-dosage CQ (600 mg CQ; 4 × 150 mg tablets twice daily for 10 days; total dose 12 g) or low-dosage CQ (450 mg CQ; 3 × 150 mg tablets and 1 placebo tablet twice daily on day 0, 3 × 150 mg tablets plus 1 placebo tablet once a day followed by 4 placebo tablets from day 1 to day 4, then 4 placebo tablets twice daily from day 5 to day 9; total dose 2.7 g).
My mistake. Thank you
very stupid.
it is too high a dose to begin with
AND QC is more dangerous than HCQ
because of rapid human cell membrane
penetration.
What’s your point?
You had bronchitis, not Covid19:
You used three antibiotics with steroids and inhaler, not Zelenko cocktail. What is the relevance of your 12 weeks ordeal? Did you experience cardiac problems and how your not-knowledge of the Az potential side effects adds to the subject of discussion you are trying to generate.
MaylA GabrielA SilvA BorbA
You think you did
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