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Scientific misconduct? Laura Ingraham shreds media fawning over weak study that pans Hydroxychloroquine
Biz Pac Review ^ | 04/23/2020 | Vivek Saxena

Posted on 04/23/2020 11:57:21 AM PDT by SeekAndFind

After weeks of ignoring testimony from doctors speaking about the positive effects of hydroxychloroquine as it pertains to treating coronavirus patients, and after ignoring at least one peer-reviewed study that demonstrated these same effects, members of the left-wing media are in an uproar over a single non-peer-reviewed study that belies these prior findings.

“A malaria drug widely touted by President Donald Trump for treating the new coronavirus showed no benefit in a large analysis of its use in U.S. veterans hospitals. There were more deaths among those given hydroxychloroquine versus standard care,” the Associated Press reported Tuesday, citing a new study.

However, the AP warned that the study “was not a rigorous experiment” and had not yet “been reviewed by other scientists.”

Nevertheless, within minutes of this news breaking, condemnations against anyone who had touted the potential of hydroxychloroquine began pouring in from left-wing media stars.

Look:

Amid the news that hydroxychloroquine is actually more dangerous than beneficial, this video might come in handy when the lawsuits start rolling in.pic.twitter.com/nC4Ve1NBNQ

— Brian Tyler Cohen (@briantylercohen) April 21, 2020

I’m old enough to remember the wall-to-wall hydroxychloroquine sales pitch from a bunch of self-appointed medical experts.

— Dan Rather (@DanRather) April 22, 2020

What’s the matter @FoxNews? Hydroxychloroquine got your tongue?

— Joe Walsh (@WalshFreedom) April 22, 2020

When are we just going to say the president is personally responsible for American deaths? https://t.co/sJ2ga0FjxU

— S.E. Cupp (@secupp) April 22, 2020

Fox News host Laura Ingraham eventually responded to this partisan sniping, which is being repeated nonstop on mainstream airways, later Wednesday evening.

In an eight-minute-long segment, she disputed the left’s veritable propaganda by citing all the counter-facts that the left-wing press have conveniently ignored.

For instance, she noted, “A survey or study released yesterday on hydroxychloroquine for use on COVID patients is shockingly irresponsible and, as top virologists are saying, perhaps even agenda-driven.”

Fact-check: TRUE.

In a tweet posted earlier Wednesday, world-renowned physician and microbiologist Dr. Didier Raoult, MD, PhD, accused the study of containing “three major biases that invalidate its conclusions.”

Look:

L’étude publiée en pre-print le 21/04 sur Medrxiv par Maganoli et al comporte trois biais majeurs qui invalident ses conclusions, de toute manière absurdes et incompatibles avec la littérature. Nous avons détaillé ces biais dans la lettre ci-dessous.https://t.co/f8s7fKSg8x

— Didier Raoult (@raoult_didier) April 22, 2020

A Google translation of his tweet reads as follows: “The study published in pre-print on 21/04 on Medrxiv by Maganoli et al contains three major biases that invalidate its conclusions, in any case absurd and incompatible with the literature. We have detailed these biases in the letter below.

“Maganoli” refers to Dr. Joseph Magagnoli, the lead researcher on the team that conducted the study.

After playing clips of left-wing media stars such as CNN chief media correspondent and political commentator Brian Stelter disparaging Fox News’ credibility (ironically enough) over its continued interest in hydroxychloroquine as a potential coronavirus cure, Ingraham then turned to Raoult ‘s own findings.

“Renowned French virologist Dr. Didier Raoult released his own study on hydroxychloroquine and azithromycin just a few weeks ago. It demonstrated 91 percent effectiveness in more than 1,000 patients, with zero side effects,” she said.

This is true, though this study was conveniently ignored by the left-wing press, which predictably chose to smear Raoult — never mind that his peer-reviewed study involved far more patients than Magagnoli’s study, which reportedly involved only 368 patients.

“Well today, that same professor, who’s a renowned infectious disease expert, released a devastating response to the researchers who looked at the Veterans Affairs patients,” Ingraham continued.

This is also true.

“In the current period, it seems that passion dominates rigorous and balanced scientific analysis and may lead to scientific misconduct. The article by Magagnoli et al. (Magagnoli, 2020) is an absolutely spectacular example of this,” Raoult wrote.

“Indeed, in this work, it is concluded, in the end, that hydroxychloroquine (HCQ) would double the mortality in patients with COVID with a fatality rate of 28% (versus 11% in the NoHCQ group), which is extraordinarily hard to believe.”

View his full letter below:

This letter is also being ignored by the left-wing press.

Raoult cited three notable biases, including the fact that “the ‘untreated’ group actually received azithromycin in 30% of cases, without this group being analyzed in any distinct way. Azithromycin is also a proposed treatment for COVID (Gautret, 2020) with in vitro efficacy (Andreani, 2020), and to mix it with patients who are supposedly untreated is something that is closer to scientific fraud than reasonable analysis.”

“Altogether these 3 voluntary biases are all pushing to the idea of dangerosity of hydroxychloroquine safest drug as reported on nearly 1 million people (Lane, 2020),” his letter concluded. “All in all, this is a work that shows that, in this period, it is possible to propose things that do not stand up to any methodological analysis to try to demonstrate that one is right.”

All of this isn’t to say that hydroxychloroquine is or isn’t beneficial. Nobody, including Ingraham, has stated that it is beneficial. They have however suggested that yes, there may be some benefits to it, and more studies would, therefore, be useful.

“Like many others, I agree that wider studies, of course, they should be conducted,” Ingraham noted. “They should be ongoing to determine the efficacy of this drug and any.”

The problem is that, just as the left-wing media choose to only consider the perspectives of scientists and doctors whose findings benefit their preferred narrative, so too they choose to only consider those studies that benefit their preferred narrative.

“But why deny or even mention the positive results from legitimate studies in favor of the shoddy surveys like the one we just discussed?” Ingraham continued.

Because, she concluded, of something called Trump Derangement Syndrome.

Listen to her whole segment below:

CLICK ABOVE LINK FOR THE VIDEO



TOPICS: Crime/Corruption; Culture/Society; News/Current Events
KEYWORDS: covid19; hcq; hcqtreatment; hydroxychloroquine; ingraham; lauraingraham; media; vastudy
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1 posted on 04/23/2020 11:57:21 AM PDT by SeekAndFind
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To: SeekAndFind

btt


2 posted on 04/23/2020 11:58:22 AM PDT by KSCITYBOY (The media is corrupt)
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To: SeekAndFind

3 posted on 04/23/2020 11:58:32 AM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

yep-they skipped the part about it being not rigorous and missed that it is not the largest study with at least 3 larger ones out there.

Suddenly if there is a negative report we don’t seem to require that it be rigorous or even peer reviewed. Would love to see more interviews like this one with Dr Zelenko who has a much larger study than the one cited https://www.dennisprager.com/video/dr-zelenko-this-is-a-game-changer-potentially/


4 posted on 04/23/2020 12:00:01 PM PDT by TECTopcat (e)
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To: TECTopcat

I want to continue seeing large studies from all over the planet, drowning out the phoney narrative by how widespread successful use has already become.


5 posted on 04/23/2020 12:06:53 PM PDT by MrEdd (Caveat Emptor)
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To: TECTopcat
There is one goal with this virus, immunity, but three ways to reach it as a society:

1) Open everything up and let all who will get infected catch the virus (Sweden is trying that, it's called herd immunity; it would definitely solve the SS shortfall problem looming)

2) Keep everything locked down and wait until a vaccine is proven to yield immunity (and even an effective vaccine is only about sixty percent effective in yielding immunity on an individual basis; plus vaccines have scary side effects and this one coming will have a Gates data dot for everyone who gets it side effect)

3) Make a drug cocktail like HCQ + Doxycycline + zinc supplementation available (without restriction to hospitals only), so every physician and physician's assistant can write the scripts at first sign of a symptom and open the nation up to go back to being GREAT.

Since it is the human body immune system which defeats any virus that is defeated, reducing the viral load and keeping inflammation down is the best way to give the immune system a shot at developing immunity.

 Hydroxychloroquine appears to have two sides to its efficacy: a) the drug has been proven as an inflammation reducer (used in RA and Lupus, and now with covid patients to reduce their airway inflammation); b) Hydroxychloroquine is a proven ionophore, ferrying ZINC into the infected cells where ZINC works to stop the viral replication thus reducing viral load.

So which of the three ways to have immunity in a society do you think the globalist oligarchy has in mind for America? And which of the three means to immunity do you think saves people and the last great hope for humanity, America?

6 posted on 04/23/2020 12:08:20 PM PDT by MHGinTN (A dispensation perspective is a powerful tool for discernment)
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To: TECTopcat

Response to Magagnoli, MedRxiv, 2020

Matthieu MILLION1,2, Yanis ROUSSEL 1,2, Didier RAOULT 1,2
1

IHU-Méditerranée Infection, Marseille, France
2

Aix Marseille Univ, IRD, AP-HM, MEPHI, Marseille, France

In the current period, it seems that passion dominates rigorous and balanced scientific analysis and may lead to scientific misconduct. The article by Magagnoli et al. (Magagnoli, 2020) is an absolutely spectacular example of this. Indeed, in this work, it is concluded, in the end, that hydroxychloroquine (HCQ) would double the mortality in patients with COVID with a fatality rate of 28% (versus 11% in the NoHCQ group), which is extraordinarily hard to believe. The analysis of the data shows two major
biases, which show a welling to be convinced before starting the work :

The first is that lymphopenia is twice as common in the HCQ groups (25% in the HCQ, 31% in the HCQ+AZ group versus 14% in the no HCQ group, p =.02) and there is an absolute correlation between lymphopenia (<0.5G/L) and fatality rate, which is well known (Tan, 2020) and confirmed here : 28% deaths, 22% and 11% in the HCQ, HCQ+AZ and No HCQ group, respectively. Lymphopenia is the most obvious criterion of patient severity (in our cohort, lymphocytes in dead individuals (n=22, mean ±
standard deviation, 0.94 ± 0.45), versus in the living (n=2405, 1.79 ± 0.84, p < .0001)). As the authors acknowledge, the severity of the patients in the different groups was very different, and their analysis can only make sense if there is a selection of patients with the same degree of severity, i.e.
the same percentage of lymphopenia.

The second major bias is that in an attempt to provide meaningful data, by eliminating the initial severity at the time of treatment, two tables are shown: one table where drugs are prescribed before intubation, and which shows no significant difference in the 3 different groups (9/90 (10%) in the HCQ group, 11/101 (10. 9%) HCQ+AZ, and 15/177 (8.5%) in the group without HCQ, chi-square = 0.47, ddl = 2, p = 0.79), and one table, where it is not clear when the drugs were prescribed, where there are significant differences. These differences are most likely related to the fact that the patients had been intubated for some before receiving hydroxychloroquine in desperation. It is
notable that this is unreasonable at the time of the cytokine storm, as it is unlikely that hydrochloroquine alone would be able to control patients at this stage of the disease.

Moreover, incomprehensibly, the “untreated” group actually received azithromycin in 30% of cases, without this group being analyzed in any distinct way. Azithromycin is also a proposed treatment for COVID (Gautret, 2020) with in vitro efficacy (Andreani, 2020), and to mix it with patients who are
supposedly untreated is something that is closer to scientific fraud than reasonable analysis.

Altogether these 3 voluntary biases are all pushing to the idea of dangerosity of hydroxychloroquine safest drug as reported on nearly 1 million people (Lane, 2020).

All in all, this is a work that shows that, in this period, it is possible to propose things that do not stand up to any methodological analysis to try to demonstrate that one is right.

____________________________________________________________________________

References

Andreani J, Le Bideau M, Duflot I, Jardot P, Rolland C, Boxberger M, Wurtz N, Rolain JM, Colson P, La Scola B, Raoult D. In vitro testing of combined Hydroxychloroquine and Azithromycin on SARS-CoV-2 shows synergistic effect. Microbial pathogenesis. 2020. In press.

Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE, Dupont HT, Honoré S, Colson P, Chabrière E, La Scola B, Rolain JM, Brouqui P, Raoult D.
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label nonrandomized clinical trial. Int J Antimicrob Agents. 2020 Mar 20:105949. doi:
10.1016/j.ijantimicag.2020.105949.

Lane JCE, Weaver J, Kostka K, et al. Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study. medRxiv 2020.04.08.20054551; doi:
https://doi.org/10.1101/2020.04.08.20054551

Magagnoli J, Narendran S, Pereira F, Cummings T, Hardin JW, Sutton SS, Ambati J. Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19. medRxiv 2020.04.16.20065920; doi: https://doi.org/10.1101/2020.04.16.20065920

Tan, L., Wang, Q., Zhang, D. et al. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Sig Transduct Target Ther 5, 33 (2020). https://doi.org/10.1038/s41392-020-0148-4


7 posted on 04/23/2020 12:09:22 PM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Damn, these ChiComDems sure are scummy. I know people saved with the HCQ therapy and it’s also well known around the country as retold by the victims.

The Dem Media are absolute evil.


8 posted on 04/23/2020 12:23:28 PM PDT by romanesq (Flubro, from the people who brought you the stupidity of grifters & the letter Q)
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To: SeekAndFind

[[and one table, where it is not clear when the drugs were prescribed, ]]

‘Not Clear’? I thought this was a study? What kind of study doesn’t even know when the drugs were administered? ink-


9 posted on 04/23/2020 12:28:03 PM PDT by Bob434
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To: romanesq

As are the4 governors who are denying it to people unless they are on ventilators when it’s too late- pure evil- playing god with people’s lives- by withholdign a lfie savign drug in the early stages when it has been proven to be most effective by numerous actual legit studies and trials now


10 posted on 04/23/2020 12:29:47 PM PDT by Bob434
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To: SeekAndFind

Laura Ingraham was great on this. The survey of a study because they admit they didn’t actually do a study was a complete joke. And yet the media out of Trump derangement syndrome touted it as a complete indictment of the President. The French doctor roasted them on the ridiculous facts and conclusions they drew from this. And as Laura pointed out when you say the group that survived were given nothing and in the footnotes you note that some of them were given Azithromycin, that’s just fraud. And yet the press went wild with the story.


11 posted on 04/23/2020 12:36:10 PM PDT by freefdny
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To: SeekAndFind

Evil scum Democrats.


12 posted on 04/23/2020 12:42:19 PM PDT by stinkerpot65 (Global warming is a Marxist lie.)
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To: SeekAndFind

Every news story about hydroxychloroquine includes the mandatory words about Trump “pushing,” “touting” or “peddling” the drug. That explains why they are trashing the drug. Their total hatred for Trump has spilled over, and they are now hating a drug that can save people.


13 posted on 04/23/2020 12:54:44 PM PDT by I want the USA back (I fear my government more than the bug.)
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To: SeekAndFind
Dr Rault's response of 22 April 2020, English: Response to Magagnoli MedRxiv, 2020
PDF Link here

Selected points:

"In the current period, it seems that passion dominates rigorous and balanced scientific analysis and may lead to scientific misconduct. Thearticle by Magagnoli et al. (Magagnoli, 2020) is an absolutely spectacular example of this."

"The first is that lymphopenia is twice as common in the HCQ groups (25% in the HCQ, 31% in the HCQ+AZ group versus 14% in the no HCQ group, p =.02) and there is an absolute correlation between lymphopenia(<0.5G/L) and fatality rate, which is well known "

"The second major bias is that in an attempt to provide meaningful data, by eliminating the initial severity at the time of treatment, two tables are shown: one table where drugs are prescribed before intubation, ... These differences are most likely related to the fact that the patients had been intubated for some before receiving hydroxychloroquine in desperation."

"Moreover, incomprehensibly, the “untreated”group actually received azithromycin in 30% of cases, without this group being analyzed in any distinct way. Azithromycin is also a proposed treatment for COVID(Gautret, 2020)with in vitro efficacy (Andreani, 2020), and to mix it with patients who are supposedly untreated is something that is closer to scientific fraud than reasonable analysis."

Altogether these 3 voluntary biases are all pushing to the idea of dangerosity of hydroxychloroquine safest drug as reported on nearly 1 million people (Lane, 2020)."

"All in all, this is a work that shows that, in this period, it is possible to propose things that do not stand up to any methodological analysis to try to demonstrate that one is right."

Summary (hopefully correct):
Test group was already at high risk of death with covid-19 regardless of care.
Many in test group were intubated, which usually means death regardless of care.
The control group was not much of a control group.

Conclusion:
Dr. Rault is very good at his job.

14 posted on 04/23/2020 1:04:59 PM PDT by Widget Jr
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To: All

VA director also stated that the HCQ was given to this group of vets who where already near the end of their lives.


15 posted on 04/23/2020 1:18:15 PM PDT by mmichaels1970
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To: All
“That’s just an observational study. It’s not a clinical study. It was done on a small number of veterans; sadly, those of whom were in the last stages of life, and the drug was given to them.”
16 posted on 04/23/2020 1:19:54 PM PDT by mmichaels1970
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To: MHGinTN

BUMP!! Excellent post. That’s is exactly!


17 posted on 04/23/2020 1:46:02 PM PDT by upchuck (Dan Bongino: The Democrats are The Virus)
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To: SeekAndFind

bkmk


18 posted on 04/23/2020 2:03:57 PM PDT by Sergio (An object at rest cannot be stopped! - The Evil Midnight Bomber What Bombs at Midnight)
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To: SeekAndFind; All

To stop the return of manufacturing of products back to the US that went to China. China backers here who’s family members are making millions from China through their political connections will be hit hard are also claiming that Trump’s alleged stock ownership in a quinine pills maker claim its a controlling interest in a product to be totally ineffective and when used requires a severe restriction of movement when near a possible carrier known as a shutdown scaring everybody into the toilet paper shortage because of its rapid transmission.


19 posted on 04/23/2020 2:18:55 PM PDT by mosesdapoet (mosesdapoet aka L.J.Keslin posting here for the record hoping somebody might read and pass around)
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To: SeekAndFind

Politics over science.


20 posted on 04/23/2020 2:43:30 PM PDT by TBP (Progressives lack compassion and tolerance. Their self-aggrandizement is all that matters.)
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