Posted on 04/23/2020 11:57:21 AM PDT by SeekAndFind
btt
yep-they skipped the part about it being not rigorous and missed that it is not the largest study with at least 3 larger ones out there.
Suddenly if there is a negative report we don’t seem to require that it be rigorous or even peer reviewed. Would love to see more interviews like this one with Dr Zelenko who has a much larger study than the one cited https://www.dennisprager.com/video/dr-zelenko-this-is-a-game-changer-potentially/
I want to continue seeing large studies from all over the planet, drowning out the phoney narrative by how widespread successful use has already become.
1) Open everything up and let all who will get infected catch the virus (Sweden is trying that, it's called herd immunity; it would definitely solve the SS shortfall problem looming)2) Keep everything locked down and wait until a vaccine is proven to yield immunity (and even an effective vaccine is only about sixty percent effective in yielding immunity on an individual basis; plus vaccines have scary side effects and this one coming will have a Gates data dot for everyone who gets it side effect)
3) Make a drug cocktail like HCQ + Doxycycline + zinc supplementation available (without restriction to hospitals only), so every physician and physician's assistant can write the scripts at first sign of a symptom and open the nation up to go back to being GREAT.
Since it is the human body immune system which defeats any virus that is defeated, reducing the viral load and keeping inflammation down is the best way to give the immune system a shot at developing immunity.
Hydroxychloroquine appears to have two sides to its efficacy: a) the drug has been proven as an inflammation reducer (used in RA and Lupus, and now with covid patients to reduce their airway inflammation); b) Hydroxychloroquine is a proven ionophore, ferrying ZINC into the infected cells where ZINC works to stop the viral replication thus reducing viral load.
So which of the three ways to have immunity in a society do you think the globalist oligarchy has in mind for America? And which of the three means to immunity do you think saves people and the last great hope for humanity, America?
Response to Magagnoli, MedRxiv, 2020
Matthieu MILLION1,2, Yanis ROUSSEL 1,2, Didier RAOULT 1,2
1
IHU-Méditerranée Infection, Marseille, France
2
Aix Marseille Univ, IRD, AP-HM, MEPHI, Marseille, France
In the current period, it seems that passion dominates rigorous and balanced scientific analysis and may lead to scientific misconduct. The article by Magagnoli et al. (Magagnoli, 2020) is an absolutely spectacular example of this. Indeed, in this work, it is concluded, in the end, that hydroxychloroquine (HCQ) would double the mortality in patients with COVID with a fatality rate of 28% (versus 11% in the NoHCQ group), which is extraordinarily hard to believe. The analysis of the data shows two major
biases, which show a welling to be convinced before starting the work :
The first is that lymphopenia is twice as common in the HCQ groups (25% in the HCQ, 31% in the HCQ+AZ group versus 14% in the no HCQ group, p =.02) and there is an absolute correlation between lymphopenia (<0.5G/L) and fatality rate, which is well known (Tan, 2020) and confirmed here : 28% deaths, 22% and 11% in the HCQ, HCQ+AZ and No HCQ group, respectively. Lymphopenia is the most obvious criterion of patient severity (in our cohort, lymphocytes in dead individuals (n=22, mean ±
standard deviation, 0.94 ± 0.45), versus in the living (n=2405, 1.79 ± 0.84, p < .0001)). As the authors acknowledge, the severity of the patients in the different groups was very different, and their analysis can only make sense if there is a selection of patients with the same degree of severity, i.e.
the same percentage of lymphopenia.
The second major bias is that in an attempt to provide meaningful data, by eliminating the initial severity at the time of treatment, two tables are shown: one table where drugs are prescribed before intubation, and which shows no significant difference in the 3 different groups (9/90 (10%) in the HCQ group, 11/101 (10. 9%) HCQ+AZ, and 15/177 (8.5%) in the group without HCQ, chi-square = 0.47, ddl = 2, p = 0.79), and one table, where it is not clear when the drugs were prescribed, where there are significant differences. These differences are most likely related to the fact that the patients had been intubated for some before receiving hydroxychloroquine in desperation. It is
notable that this is unreasonable at the time of the cytokine storm, as it is unlikely that hydrochloroquine alone would be able to control patients at this stage of the disease.
Moreover, incomprehensibly, the “untreated” group actually received azithromycin in 30% of cases, without this group being analyzed in any distinct way. Azithromycin is also a proposed treatment for COVID (Gautret, 2020) with in vitro efficacy (Andreani, 2020), and to mix it with patients who are
supposedly untreated is something that is closer to scientific fraud than reasonable analysis.
Altogether these 3 voluntary biases are all pushing to the idea of dangerosity of hydroxychloroquine safest drug as reported on nearly 1 million people (Lane, 2020).
All in all, this is a work that shows that, in this period, it is possible to propose things that do not stand up to any methodological analysis to try to demonstrate that one is right.
____________________________________________________________________________
References
Andreani J, Le Bideau M, Duflot I, Jardot P, Rolland C, Boxberger M, Wurtz N, Rolain JM, Colson P, La Scola B, Raoult D. In vitro testing of combined Hydroxychloroquine and Azithromycin on SARS-CoV-2 shows synergistic effect. Microbial pathogenesis. 2020. In press.
Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE, Dupont HT, Honoré S, Colson P, Chabrière E, La Scola B, Rolain JM, Brouqui P, Raoult D.
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label nonrandomized clinical trial. Int J Antimicrob Agents. 2020 Mar 20:105949. doi:
10.1016/j.ijantimicag.2020.105949.
Lane JCE, Weaver J, Kostka K, et al. Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study. medRxiv 2020.04.08.20054551; doi:
https://doi.org/10.1101/2020.04.08.20054551
Magagnoli J, Narendran S, Pereira F, Cummings T, Hardin JW, Sutton SS, Ambati J. Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19. medRxiv 2020.04.16.20065920; doi: https://doi.org/10.1101/2020.04.16.20065920
Tan, L., Wang, Q., Zhang, D. et al. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Sig Transduct Target Ther 5, 33 (2020). https://doi.org/10.1038/s41392-020-0148-4
Damn, these ChiComDems sure are scummy. I know people saved with the HCQ therapy and it’s also well known around the country as retold by the victims.
The Dem Media are absolute evil.
[[and one table, where it is not clear when the drugs were prescribed, ]]
‘Not Clear’? I thought this was a study? What kind of study doesn’t even know when the drugs were administered? ink-
As are the4 governors who are denying it to people unless they are on ventilators when it’s too late- pure evil- playing god with people’s lives- by withholdign a lfie savign drug in the early stages when it has been proven to be most effective by numerous actual legit studies and trials now
Laura Ingraham was great on this. The survey of a study because they admit they didn’t actually do a study was a complete joke. And yet the media out of Trump derangement syndrome touted it as a complete indictment of the President. The French doctor roasted them on the ridiculous facts and conclusions they drew from this. And as Laura pointed out when you say the group that survived were given nothing and in the footnotes you note that some of them were given Azithromycin, that’s just fraud. And yet the press went wild with the story.
Evil scum Democrats.
Every news story about hydroxychloroquine includes the mandatory words about Trump “pushing,” “touting” or “peddling” the drug. That explains why they are trashing the drug. Their total hatred for Trump has spilled over, and they are now hating a drug that can save people.
Selected points:
"In the current period, it seems that passion dominates rigorous and balanced scientific analysis and may lead to scientific misconduct. Thearticle by Magagnoli et al. (Magagnoli, 2020) is an absolutely spectacular example of this."
"The first is that lymphopenia is twice as common in the HCQ groups (25% in the HCQ, 31% in the HCQ+AZ group versus 14% in the no HCQ group, p =.02) and there is an absolute correlation between lymphopenia(<0.5G/L) and fatality rate, which is well known "
"The second major bias is that in an attempt to provide meaningful data, by eliminating the initial severity at the time of treatment, two tables are shown: one table where drugs are prescribed before intubation, ... These differences are most likely related to the fact that the patients had been intubated for some before receiving hydroxychloroquine in desperation."
"Moreover, incomprehensibly, the “untreated”group actually received azithromycin in 30% of cases, without this group being analyzed in any distinct way. Azithromycin is also a proposed treatment for COVID(Gautret, 2020)with in vitro efficacy (Andreani, 2020), and to mix it with patients who are supposedly untreated is something that is closer to scientific fraud than reasonable analysis."
Altogether these 3 voluntary biases are all pushing to the idea of dangerosity of hydroxychloroquine safest drug as reported on nearly 1 million people (Lane, 2020)."
"All in all, this is a work that shows that, in this period, it is possible to propose things that do not stand up to any methodological analysis to try to demonstrate that one is right."
Summary (hopefully correct):
Test group was already at high risk of death with covid-19 regardless of care.
Many in test group were intubated, which usually means death regardless of care.
The control group was not much of a control group.
Conclusion:
Dr. Rault is very good at his job.
VA director also stated that the HCQ was given to this group of vets who where already near the end of their lives.
BUMP!! Excellent post. That’s is exactly!
bkmk
To stop the return of manufacturing of products back to the US that went to China. China backers here who’s family members are making millions from China through their political connections will be hit hard are also claiming that Trump’s alleged stock ownership in a quinine pills maker claim its a controlling interest in a product to be totally ineffective and when used requires a severe restriction of movement when near a possible carrier known as a shutdown scaring everybody into the toilet paper shortage because of its rapid transmission.
Politics over science.
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