It is n excellent mechanism detail, the only problem being that it is wrong. This is not a heme issue. This is the latest and greatest error to be promulgated. And befoe you tee of the way you have on other people, I am standing at bedside treating these critically ill patients and I have not had a single death. It is NOT a hemoglobinopathy.
Zinc — our patients are on fully balanced feedings, and it is impossible to get zinc in IV unless TPN which would be contraindicated. As Zinc won’t hurt anyone, if someone want to give it — fine — but it is at best a 2B intervention. Please stop with the fake hemoglobin issues.
Do your patients not have high ferritin levels? If they do, what do you think might be causing it?
I don’t know if this sort of work is worth much but i found it interesting:
https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173
I just watched a MedCram youtube video where Dr. Seheult looked at the article I linked to. He said it’s not consistent with what he’s seeing in the COVID-19 patients he’s seeing and explained why. Said he would expect normal O2 in the plasma but low saturation if what was presented in the article was correct, but he’s seeing low O2 in the plasma and low saturation.