Posted on 03/29/2020 5:13:17 PM PDT by SeekAndFind
A decades-old anti-malaria drug holds promise as a treatment for coronavirus and is being tested in a major clinical trial.
The University of Oxford is testing hydroxychloroquine on 3,000 high-risk coronavirus patients to see if it can alleviate the worst of the symptoms.
The researchers are hopeful that because the drug reduces inflammation in malaria patients it could also help some people fight Covid-19 - since many of the worst cases of coronavirus involve inflammation.
“This trial is aimed at those people who are at higher risk of complications but are not yet that sick that they need to go to hospital. We’re hoping to find drugs that might prevent that kind of disease progression to help them get better quicker,” Professor Chris Butler, of Oxford University, told BBC Radio 6.
Drug also being tested in hospitals
A separate trial, also by Oxford University, will test hydroxychloroquine on patients who are so ill they have already been taken to hospital.
There are currently no treatments for Covid-19 although researchers all over the world are working furiously to develop vaccines and other treatments.
However, given the length of time it can take to pass the safety and effectiveness tests required before regulators clear a new drug scientists are hopeful that some existing treatments, such as this one, might work.
Aberdeen tests Since hydroxychloroquine already passed through the regulatory process and demonstrated to be safe for treating malaria over a period of years, its application for Covid-19 could be relatively quick, assuming it is found to be effective.
Meanwhile, researchers at Dundee University have identified the 38 proteins created by Covid-19 that prompt the immune system to generate the antibodies that fight the disease.
Over the next four months they will manufacture these proteins and generate antibodies from them. They will then hand them over to Glasgow University which will conduct tests on them.
“These antibodies represent a unique set of tools to study the inner workings of COVID-19. They will help future research aimed at understanding fundamental COVID-19 biology and the quest to develop new drugs [for coronavirus patients],” said Professor Dario Alessi, of Dundee University.
As soon as each of these antibodies is generated we will make them available to the worldwide researcher community, he added.
Dundee and Glasgow are also studying 10 key components of the biology of SARS and MERS – the most severe human coronavirus infection types – to learn more about how to protect against any future novel virus outbreaks and prevent them escalating into pandemics.
They also need to be doing studies with hydroxychloroquine + azithromycin and studies with hydroxychloroquine + zinc and studies with hydroxychloroquine + azithromycin + zinc.
Why are people dragging their feet so much on this?
Dr Zelenko has perfected a therapy in the United States which has three components proven to work, every time, if administered before the lungs fill with mucus.
What is being used is a combination of drugs , not just Hydroxy-chloroquin, which shows that the Democrats and Big Pharm do not want what is working should be understood by the People.They rail against a single part of the therapy without revealing the rest of it because IT WORKS.But it has to be administered before the lungs fill with mucus.
But what President Trump’s agent, Rudy Giuliani has done is created a populist end run around the CDC ( Fauci) and the FDA. This to save lives.( See video link below)
If you are a Trump supporter you know what to do. Contact your physician and ask whether this therapy can be available if you need it. If not shop around. And if you find a Jewish doctor, you’re in like Flynn.The therapy cost of the drugs is $20.00, so it won’t break you.
Its really up to you.
President Trump has arranged for millions of dosages to come into our country from Israel’s Teva Corporation....Free. Availability will be no problem.
Secondly there is a pretty sure possibility that hydroxy-chloroquine acts as an prophylaxis, taking 1 x 200 mg HCQ per day along with a 200 gram Zinc supplement.Almost all of the front line doctors in NYC are doing this, so why not everybody. We soon will have enough HCQ to do that.
****************************
THIS CAN SAVE YOUR LIFE
EXCELLENT NEWS: Hydroxychloroquine Treatment Effective on 699 Patients
Must see video: https://www.youtube.com/watch?v=1TJdjhd_XG8&t=586s
Dr. Vladimir (Zev) Zelenko
Board Certified Family Practitioner
501 Rt 208, Monroe, NY 10950
845-238-0000
March 23, 2020
To all medical professionals around the world:
My name is Dr. Zev Zelenko and I practice medicine in Monroe, NY. For the last 16 years, I have cared for approximately 75% of the adult population of Kiryas Joel, which is a very close knit community of approximately 35,000 people in which the infection spread rapidly and unchecked prior to the imposition of social distancing.
As of today my team has tested approximately 200 people from this community for Covid-19, and 65% of the results have been positive. If extrapolated to the entire community, that means more than 20,000 people are infected at the present time. Of this group, I estimate that there are 1500 patients who are in the high-risk category (i.e. >60, immunocompromised, comorbidities, etc).
Given the urgency of the situation, I developed the following treatment protocol in the pre-hospital setting and have seen only positive results:
1. Any patient with shortness of breath regardless of age is treated.
2. Any patient in the high-risk category even with just mild symptoms is treated.
3. Young, healthy and low risk patients even with symptoms are not treated (unless their circumstances change and they fall into category 1 or 2).
My out-patient treatment regimen is as follows:
1. Hydroxychloroquine 200mg twice a day for 5 days
2. Azithromycin 500mg once a day for 5 days
3. Zinc sulfate 220mg once a day for 5 days
The rationale for my treatment plan is as follows. I combined the data available from China and South Korea with the recent study published from France (sites available on request). We know that hydroxychloroquine helps Zinc enter the cell. We know that Zinc slows viral replication within the cell. Regarding the use of azithromycin, I postulate it prevents secondary bacterial infections. These three drugs are well known and usually well tolerated, hence the risk to the patient is low.
Since last Thursday, my team has treated approximately 350 patients in Kiryas Joel and another 150 patients in other areas of New York with the above regimen.
Of this group and the information provided to me by affiliated medical teams, we have had ZERO deaths, ZERO hospitalizations, and ZERO intubations. In addition, I have not heard of any negative side effects other than approximately 10% of patients with temporary nausea and diarrhea.
In sum, my urgent recommendation is to initiate treatment in the outpatient setting as soon as possible in accordance with the above. Based on my direct experience, it prevents acute respiratory distress syndrome (ARDS), prevents the need for hospitalization and saves lives.
With much respect,
Dr. Zev Zelenko
It could be relatively quicker if they would just open their eyes and clean out their ears rather than digging through a bunch of red tape just to cover their asses.
We need info over the next 4-8 DAYS.
In four months this thing will be over.
One way or another.
.
OK, which of these experimental drugs are going to turn people into Zombies?
Paging Dr Fauxi...
Clearly this inexpensive cure would not make Big Pharma happy...
“OK, which of these experimental drugs are going to turn people into Zombies?”
.
Hydroxychloroquine was approved by the FDA for lupus in 1955. (65 years experience)
Azithromycin was discovered 1980 by Pliva, and approved for medical use in 1988. (32 years experience)
Not a whole lot of zombie action going on...
.
Considering that it usually takes several years — often seven — to conduct clinical trials, I see no foot-dragging. Quite the opposite.
Clinical trials can only be sped up so much — it takes time for results to manifest themselves. That timing is up to the virus and the patient — the researcher cannot make it go any faster.
But these aren’t new drugs. I’d think that should speed up the trials considerably.
"It takes on average 12 years and over US$350 million to get a new drug from the laboratory onto the pharmacy shelf. Once a company develops a drug, it undergoes around three and a half years of laboratory testing, before an application is made to the U.S. Food and Drug Administration (FDA) to begin testing the drug in humans. Only one in 1000 of the compounds that enter laboratory testing will ever make it to human testing."
https://www.drugs.com/fda-approval-process.html
Why no small scale trials of the combinations of drugs I mentioned in my earlier post? Red tape? Or do you think they may have just not been announced yet?
You probably know more than me about all of this. However, I know that Trump is an extraordinary crisis manager. There should be no doubt that things are proceeding on multiple fronts, and that Trump is out in front, cutting red tape.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.