Posted on 03/15/2020 10:51:27 PM PDT by TECTopcat
David Sinclair, PhD AO @davidasinclair
Since my Harvard lab closed yesterday, I've been reading and interpreting this week's published papers on #COVID19. What follows is a thread of information, my interpretation, links to sources & predictions. Let's start with what you need to know... #coronavirus #COVIDー19
Treatments that seem to work are chloroquine (a cheap malarial drug), Gilliad's remdesivir with interferon-beta (in clinical trials from COV-19), plasma from recovered patients, and a steroid (methylprednisilone). Doctors in US are now using remdesivir off-label...
SARS-CoV2 attacks pneumocytes in lung, intestine, heart & cells lining blood vessels. In lung, CoV2 prevents cells from making biological detergents to keep lung passages open. Acute respiratory distress follows. O2 levels fall..but there's may be a dangerous underlying process.. ..new work out of China yesterday says COVID-19 might also involve abnormal blood production. CoV genes 1 & 8 are predicted to interfere with heme, the red compound in blood, by kicking out the iron. Would explain why chloroquine seems effective as a treatment #CoronaVirusUpdate
Chloroquine is predicted to prevent orf1ab, ORF3a and ORF10 from attacking heme (red in red blood cells) and inhibit the binding of ORF8 to heme. Although 99% of the virus is seemingly stable, what's disturbing is ORF 1 and 8 are mutating the fastest...
..Positions nt28144 in ORF 8 and nt8782 in ORF1 are evolving. Samples out of China show they'd mutated 30.53% (29/95) and 29.47% (28/95), respectively. I'm currently figuring out why these are the ones mutating and how that would change the situation...
It may explain why diabetics and elderly are more susceptible. Blood sugar levels usually increase as we get older, increasing the amount of glycated hemoglobin (HbA1c) (I've tweeted about this before). The authors suggest these people would be more susceptible to because... ...the virus could more easily disrupt the heme in red blood cells. If so, the virus is very smart: it destroys the lung so patients can't take up oxygen AND reduces the body's ability to carry oxygen. (For this & other reasons, you should eat healthily the next 2 years)...
These ideas are testable. COVID-19 should correlate with HbA1c levels (seems true). Patients should have abnormalities in heme/porphyrin & they might have higher levels of free iron in tissues & blood. I will update with more info as it comes in. Stay safe. Below are links... Blood, HbA1c, and chloroquine COVID-19 Disease: ORF8 and Surface Glycoprotein Inhibit Heme Metabolism by Binding to Porphyrin COVID-19 Disease: ORF8 and Surface Glycoprotein Inhibit Heme Metabolism by Binding to Porphyrin https://tinyurl.com/w28et45
CoV2 mutations tinyurl.com/secncmf Symptoms tinyurl.com/ubncbgn Susceptibility/Risk tinyurl.com/vexo5vl Fatality tinyurl.com/sb8qpza Therapies tinyurl.com/vrm7f5j Remdesivir
There is an RCT underway in Seattle but most use is, as you say, under compassionate use protocols.
You can’t be “off-label” when you don’t HAVE a label.
HollyB wrote:
“Vit D, cytokine storms, avoiding elderberry, “
Which are good to take, D but not elderberry?
Sure there is. Says so right their on the bottle. I picked up some over the weekend.....because I like the taste
I was ecstatic with my last A1c of 6.3 as my previous one 3 months earlier was 10.5. Yes I’m being treated for diabetes for the last 5 years. What changed was I went completely to a low carb diet. Dr was adamant about starting me on daily insulin and I said no way. 10.5 was a kick in the butt to make me see the light on my poor diet choices. I’m pretty sure CC knows he’s diabetic and is being treated.
Ping
Hydroxychloroquine is more effective, safer, and more widely available for use as a zinc ionophore. OTC quercetin is also a zinc ionophore but the dosage is unknown.
Watch the movie Omega man w/ Charlton Heston
When you have a sec, Read over this article or skim over it. . The most recent is saying elderberry will jack up the immune system to cause this effect. I dont believe it tho.
Oh my. Youve done fantastic !!!
Yes, I am insulin dependent and under treatment. I am also physically disabled due to a degenerative birth defect which forced my early retirement from law enforcement. For somebody whom regular exercise is problematic, 6.9 is great. Would I like it lower? Of course. But 6 months ago it was a over 10. I’ll take my success wherever I can find it.
CC
Wow. I hope you're in total remission. My wife is a cancer survivor, in partial remission. Since we're seniors, we're trying to be careful when going out because of her reduced immunity. Cancer altering DNA is something we don't think about.
Youve done fantastic. Sorry for the post. I assumed you knew, but you said it so casually.
Yes Im in remission. But, as you probably have seen with your wife - it changes us. Were never like how we were before.
Yep, it still has quinine in it. Just not at therapeutic levels like it once did.
CC
there is a body of thought that older people can tolerate a little bit higher A1Cs....so don’t dispare...
I’m not worried. My doctor said I done good. That’s good enough for now.
CC
unknown because of how ingested
A few tenths percent can be very effective
Be that as it may I think its interesting that South Korea was getting good results from quinine and zinc
Definitely. My wife has been through several surgeries, lots of chemo and radiation therapy for several types of cancer. She fears her checkups, because she never knows if scans or x-rays will show a flare-up (which has happened). Doctors told her it will be with her the rest of her life and could flare up. Some years back, she had a strong rapport with a cancer doctor that was treating her. During one bout with cancer, she got emotional and told the doctor that he didn't understand what she was going through. Doctor gently told her that he did understand. He had been diagnosed with cancer, and died within six months. That really impacted my wife. She thanks me for helping her and being there for her, which makes me feel bad that she even has to say it.
That made me sad for her too. I understand her feelings tho. We know this doesnt effect just us, but everyone who are in our lives. Especially spouses, family/our children. I can tell you have a really good heart as you explain from here perspective. Shes fortunate to have a caring dr as well.
Shes been fighting this for a long time. Im sure she goes thru many phases mentally/emotionally about it. It always bothered me when people would say stay positive. Its hard to explain. But, it really irked me.
Is she currently in treatment ? For me, I had a stem cell transplant after getting into remission. They hoped that would be the best way to stay in remission. But, it comes with a whole different set of issues. Considering - Im doing well. But, Im pretty much house bound. Sometimes. Think - geez all this time, $, and effort put into me and all I do is stay home.
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