Well said, another great post, recommend to all.
Virginians had exhausted the soil and were facing increasing agricultural and financial problems. Virginia was the largest state in the beginning, and Virginians weren't opposed to maintaining that advantage by developing manufactures. Even George Washington wanted that canal to the interior built. North Carolinians were middling folk stuck between the aristocrats of Virginia and South Carolina and looking for a role to play. Kentuckians wanted to build roads and support their hemp-growing.
There was much room for cooperation between the regions. Then Cotton became King and every compromise or accommodation that happened earlier came to look like a betrayal of the cotton states and a theft from the wildly profitable plantation economy. Measures that were generally accepted in the early days as strengthening the national economy came to be seen as assaults on the cotton states' cash cow.