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To: NobleFree
As soon as you feel any effected from alcohol, such as being "relaxed," you've overcome the body’s natural detoxifying process. So your statement could be considered correct only under some highly strained daffynition of "a lot in a short time."

No, you haven't. Your alcohol dehydrogenase is still working just fine, converting alcohol to its aldehyde at the rate of about one drink per hour. "A lot of alcohol in a short time" is layman's language, which is not precise but could be interpreted into scientificese as the consumption of close to an LD50 within one hour, a level of consumption which requires medical attention. I've yet to see anyone require medical attention from drinking just enough alcohol to get dizzy.

Marijuana, on the other hand, is not water soluble. Since it is fat soluble, it very quickly goes into fat deposits throughout the body.

Where it's not binding to neuroreceptors, so having no mental effects.

Um, actually it is. You have plenty of lipids in the brain where THC (and the other lipid soluble components of marijuana) can partition. Cell membranes are composed of lipids; thus THC etc. can partition into cell membranes as well as lipid vacuoles within cells. And that puts these chemicals in direct proximity to neuroreceptors, since receptors are located in the cell membrane and in the cytosol. Furthermore, when cannabinoids are partitioned into the lipids, they are also in close proximity to cellular machinery and nucleic acids; while the consequences are still under a great deal of study, the results of studies completed so far show that there is much to be concerned about with the growing use of marijuana. Conceptually, the fact that these exogenous bioactive compounds remain present in cells for prolonged periods of time should cause great concern.

67 posted on 05/28/2018 6:07:39 AM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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To: exDemMom
As soon as you feel any effected from alcohol, such as being "relaxed," you've overcome the body’s natural detoxifying process. So your statement could be considered correct only under some highly strained daffynition of "a lot in a short time."

No, you haven't. Your alcohol dehydrogenase is still working just fine, converting alcohol to its aldehyde at the rate of about one drink per hour.

And yet is being overcome.

"A lot of alcohol in a short time" is layman's language, which is not precise but could be interpreted into scientificese as the consumption of close to an LD50 within one hour, a level of consumption which requires medical attention. I've yet to see anyone require medical attention from drinking just enough alcohol to get dizzy.

So dizziness is not an effect of mild or moderate alcohol toxicity - toxicity kicks in only when one requires medical attention? Sounds fishy to me.

Marijuana, on the other hand, is not water soluble. Since it is fat soluble, it very quickly goes into fat deposits throughout the body.

Where it's not binding to neuroreceptors, so having no mental effects.

that puts these chemicals in direct proximity to neuroreceptors

Is "direct proximity" the same as binding? Is there any evidence for mental effects of lipid-stored THC? As far as I know, the answers are no and no.

72 posted on 05/28/2018 7:02:22 AM PDT by NobleFree ("law is often but the tyrant's will, and always so when it violates the right of an individual")
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