SUPREMACY OF THE NATIONAL GOVERNMENT
[2] This Constitution, and the Laws of the United States which shall be made in Pursuance thereof; and all Treaties made, or which shall be made, under the Authority of the United States, shall be the supreme Law of the Land; and the Judges in every State shall be bound thereby, any Thing in the Constitution or Laws of any State to the Contrary notwithstanding.
It means you still have some work to do.
Note the phrase “in Pursuance thereof”. A federal law that violates the 2nd or 10th Amendment is not a law made in persuance of the Constitution; whereas a federal law that controls immigration is in pursuance thereof.