Why limit the question to “biological” facts?
The question should be - do facts no longer matter? Does reality no longer matter.
Postmodernism which is the all the rage in colleges and the source of this insanity says NO.
Why do you think the “no Labels”/PC crowd has gone to such lengths to substitute “gender” for “sex?” Because when you’ve corrupted the language and are using the term “gender” to mean “sex,” than all bets are off.
English-only monoglots are the only ones who fall for this trap, BTW, because English is the only major language that uses natural gender exclusively.
Gender is a grammatical distinction. Sex is a biological distinction. In most other languages, it is self-evident that sex and gender are unrelated.
In English, “potato” is of neutral gender because potatoes have no sex organs. But in German, the word is of feminine gender.
In Spanish, the word for “shirt,” a man’s garment, is feminine. The word for “dress,” a woman’s garment, is masculine. And in French, the medical term for a man’s wedding tackle is feminine, while the medical term for a woman’s lady-bits is masculine.
But by accepting the introduction of terms such as “trans-gender,” you’ve fallen for their ruse.