That to secure these rights, governments are instituted among men, deriving their just powers from the consent of the governed. That whenever any form of government becomes destructive of these ends, it is the right of the people to alter or to abolish it, and to institute new government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their safety and happiness.
That circumstance did not exist in 1860. No armies were marching into their towns and seizing their citizens or their property. There was no moral or legal justification for quitting the union. Being angry isn’t justification.
I say "destructive of these ends" is entirely in the eyes of the beholder.
I personally think the Supreme Court's rulings on Roe, on Kelo, on Wickard, Obamacare and on Gay Marriage are all destructive of these ends, and in my opinion ought to be grounds for separation.
Obviously you feel these are all acceptable aspects of our governance, and you will want to insure that I am forced to comply with them.
Right? :)