And here you go again, trying to restrict this discussion to weed, when your legal argument applies to all drugs. You would more accurately ask:
"Do you agree that CO, rather than fedgov, should regulate intrastate Heroin, Crack, Meth, Cocaine, Krokidil, etc per the Tenth Amendment?
Yes, I do. Colorado is perfectly capable of exercising its own police powers. If you ship it out of state, then the feds can get involved.
The Commerce Clause gives Congress the power "To regulate commerce with foreign nations, and among the several states, and with the Indian tribes." It is one of the enumerated powers. It does not give Congress the power to regulate all commerce in any state.
Once you accept that Congress has the power over any commerce in the U.S., then the federal government is no longer a government of enumerated powers.