I believe there are more people living within a 10-11 hour drive (an important figure that roughly correlates to a one-day drive for the trucking industry) of Columbus than any other major city in North America. That's a big reason why it's become one of the biggest warehousing and logistics hubs in the U.S.
The center of population of U.S. population is in Plato, Missouri, near 37.52°N 92.17°W.
Ohio is far more amenable to business than New York has been in decades. The anti-business atmosphere in New York is palpably toxic.
The advantages of the midwest are growing with the spread of RTW even if it isn’t in Ohio. As you said there’s trucking to take into account with the Canadian manufacturing center nearby.
Mahindra is opening a factory engineering and development center over near Ann Arbor
You are spot on. My husband is in the distribution business, and Columbus is a major hub.