They will be alone, and all the nations will turn against them (which has been in the process of happening for several years and the rapidity of this has greatly increased since Obama was elected), but God engineers their isolation so that He is the only One they can turn to for help and this is the way He will bring His chosen people back to Him.
Here are a couple of articles that talk about what will happen with Israel as this age comes to a close:
Israel's Destiny
Israel's Future Destiny: Literal or Symbolic?