Well, you may not care, but in one of the most important Supreme Court decisions in modern times they DID care.
United States V Lopez, 514 US 549
https://en.wikipedia.org/wiki/United_States_v._Lopez
That case has absolutely nothing to do with the point I made.
Congress cannot enact a criminal statute that only applies to the citizens of some of the states. Exempting the residents of Colorado while prosecuting the residents of Texas for the same crime is a clear violation of the Constitution.
Lopez had nothing whatsoever to do with that issue.