Interesting!
Still, the underlying assumption being that the next pandemic will be plague/bacterial-based.
If a Spanish flu-type virus does a number, that entire evolved immunity becomes hopeless.
If you read deeply enough into the CF literature you find that there are researchers who believe that yersinia pestis kills 100% of those who do not carry a mutant CF gene. Why it doesn't kill all those folks in East Asia is simple ~ it is so virulent and deadly, it kills its human host population before it can spread very far physically.
BTW, there are those who appear to carry a natural immunity to flu. They just never get it. No one knows how many there are.