Don't nominate a candidate who won't even bring his own state into the GOP column.
In addition to the obvious problem associated with this, you end up with a handicapped candidate who has no credibility because he spends so much time trying to explain why the Marxism he supported in [INSERT NAME OF STATE HERE] was not something he would support as president.
Not only did Ryan lose his home state, but Romney lost all of his home states.
Romney lost Massachusetts, Michigan, California, and New Hampshire, I forgot about Utah, Mitt did carry that home state.