I should have said newer cars with fancier engines — my 2001 Saturn with 172,000 miles doesn’t seem to care what I feed it.
Your 2001 Saturn was designed with an eye towards potentially running on E85 (though it was never certified for it) and many GM corporate parts were rated for E85 as they were intended to be used in FFVs, so your Saturn is at least in part prepped for higher levels of ethanol in its fuel than most other vehicles.