I have a friend who lost a patch of skin about the size of a hand to a brown recluse bite.
Another friend got bit twice living in a loft apartment at a warehouse.
Yes, I saw a college-aged girl who got bit by a brown recluse in her bed. It bit the inside of her thigh and by the end of it all, she had a hole in her inner leg tissue the size of your fist where the tissue sloughed off from the poison.
She likely still has a crater there. The treatment was applying wet packing dressings until the thing decided to quit sloughing and start healing.
A Brown Recluse bite can eat a hole in your flesh as big as a softball if not treated properly. I have read the Hobo Spider bites are also very nasty.
Brown Recluse spiders swarm all over my body every night.