Yes, I saw a college-aged girl who got bit by a brown recluse in her bed. It bit the inside of her thigh and by the end of it all, she had a hole in her inner leg tissue the size of your fist where the tissue sloughed off from the poison.
She likely still has a crater there. The treatment was applying wet packing dressings until the thing decided to quit sloughing and start healing.
My friend who got bit twice (on separate occasions) got bit on the leg near his crotch and later on his lip (which required stitches). He moved out after that.